Effects of Exercise-intensity on Physiological Adaptations in Overweight and Obese

The main purpose of our study is to examine the physiological adaptations in oxygen transport chain for high-intensity exercise and moderate exercise in overweight and obese humans. The main goals are:

1. To investigate the most effective short-and long-interval training in terms of VO2max, pulmonary diffusion, cardiac output, endothelial function and mitochondrial function. 2. How these physiological adaptations affect the aerobic endurance and performance, and how this training can reduce the risk of cardiovascular diseases related to overweight and obesity.

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Key information

Conditions

Overweight Behavior Body Weight Motor Activity Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medical Faculty, Norwegian University of Science and Technology

Trondheim, Sør-Trøndelag, 7491, Norway

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

BMI > 25

Exclusion criteria

Exclusion criteria will be cardiovascular disease or another disease that is not consistent with high physical activity. Subjects should not have exercised regularly before the study.

Treatment and study plan

Long distanse moderate training

Behavioral

Moderate exercise

Long interval training

Behavioral

High-intensity exercise, long duration

Short interval training

Behavioral

High intensity exercise, short duration

Primary outcomes

Maximal oxygen uptake

Time frame: 6 weeks

Change in maximal oxygen uptake will be measured after six weeks of various exercise training and related to changes in blood volume, cardiac function, endothelial function and mitochondrial function.

Sponsors and collaborators

Lead sponsor

Norwegian University of Science and Technology

Other

Registry information

Acronym: TRENO

Important dates

Study start: 2011
Primary completion: 2012
Study completion: 2012
First posted: Oct 18, 2011
Registry last updated: Aug 2, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed