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Completed

NCT Number: NCT07507981

Effects of Exercise in Hemodialysis

Objective: To evaluate the effects of a six-month intradialytic aerobic exercise program on left ventricular ejection fraction in patients with end-stage kidney disease undergoing maintenance hemodialysis.

Materials and Methods Design: Open-label, single-center, quasi-experimental, single-group study with pre- and post-intervention measurements.

Study setting: the outpatient hemodialysis unit of the National Institute of Medical Sciences and Nutrition Salvador Zubirán.

Participants: Patients aged ≥18 years with chronic kidney disease on hemodialysis for at least three months, who are at their dry weight.

Procedures: An echocardiogram will be performed post-hemodialysis. Subsequently, patients will undergo a 30-minute intradialytic aerobic exercise program at submaximal intensity during the second hour of dialysis, three times per week for six months. At the end of the six-month period, a post-hemodialysis echocardiogram will be repeated.

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Key information

Conditions

End Stage Cronic Kidney Disease Hemodialysis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Mexico City, 14080, Mexico

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged ≥18 years
  • Receiving hemodialysis with a stable prescription for at least 3 months
  • At their prescribed dry weight
  • Provision of written informed consent

Exclusion criteria

  • Active cardiovascular disease within the past 3 months
  • Left ventricular ejection fraction <40%
  • Physical and/or cognitive impairment precluding exercise
  • Blood pressure >160/110 mmHg

Treatment and study plan

Intradialytic aerobic exercise program

Other

A six-month intradialytic aerobic exercise program consisting of 30-minute sessions at submaximal intensity, performed during the second hour of hemodialysis three times per week.

Primary outcomes

  1. Left ventricular ejection fraction

    Time frame: From study enrollment to the initiation of the exercise program (within a maximum of 6 weeks), and subsequently from completion of the exercise program to up to 6 weeks thereafter

    Left ventricular ejection fraction measured by transthoracic echocardiogram

Sponsors and collaborators

Lead sponsor

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Other

Registry information

Official study title

Effects of an Intradialytic Aerobic Exercise Program on Echocardiographic Findings in Patients With End-Stage Chronic Kidney Disease on Hemodialysis

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Apr 2, 2026
Registry last updated
Apr 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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