Effects of Exercise and Rivastigmine on Quality of Life of Alzheimer's Disease Patients

After screening and informed consent, that will be collected demographical data from patient. Another researcher will evaluate the cognition, through MMSE; the activities of daily living, through Activities of Daily Living Questionnaire of Alzheimer disease; patient and caregiver's quality of life through Quality of life scale in Alzheimer's disease (QOL-AD); functional mobility, through Time Up and Go test.

Afterwards, the pharmacist will give the medicine, orientations about its administration and clarify possible doubts. Therapy will begin with the small patch of 5 mg/24 h and, if well tolerated, the dose will be increased to the 10 mg/24 h patch.

The patients will be randomly assigned, through a computer program list, to exercise or control group. The patient and caregiver exercise group will receive information about the two-day/week exercise program at physiotherapy ambulatory. Monthly, all patients and caregiver will be clinically reevaluated during six months.

The forty minutes exercise program will include aerobic, strength, flexibility and balance training, organize in the follow sequence:

• Ten minutes of global stretching (shoulder girdle, upper limbs, lower limbs and trunk) along the beginning and final of the session. Each stretch posture will last 30 seconds.

Alternation of A and B sessions, lasting 30 minutes:

• Session A: Aerobic training on treadmill. Progression of 10 to 30 minutes of continuous aerobic activity
• Session B: - Resisted kinesiotherapy (strength training) with use of weights to be attached around the ankles and wrist of initially 1 Ib. The physiotherapist will evaluate if patient can progress to a higher weight during sessions.
• Walking over obstacles on the ground and direction change with use of cones.
• Functional activities like transfer exercise (stand/sit exercise) and squatting The monitoring of the exercise, its progress and any other observation will be register in a control form by the physiotherapist.

Inclusion criteria

• Previous diagnosis of probable Alzheimer's disease
• At least 55 years of age
• Same caregiver (familiar or paid one) for at least 3 months before, who is able to follow the patient in a two-day/week exercise program
• Do not be taking other prescribed medication for Alzheimer disease
• Treated stable hypertension

Exclusion criteria

• Mini-Mental State Examination (MMSE) score of less than 12
• Can't follow simple commands;
• Can't answer two or more items of Quality of life questionnaire
• Practiced regular exercise or physiotherapy/ occupational therapy in the last two months.
• Diagnosed psychiatric condition (including depression).
• Use of neuroleptic drugs
• Orthopedic, neurologic, or behavioral limitations that may preclude exercise training
• Visual or hearing impairment that may preclude exercise training or comprehension