Effects of Exercise and Inhibition of Dipeptidyl Peptidase-4 on Insulin Secretion in Subjects With Type 1 Diabetes

Inclusion criteria

• Type 1 diabetes (American Diabetes Association criteria) of > 2 year duration that is judged to be stable by the investigator
• No clinically significant change in treatment regimen for type 1 diabetes (defined as a 20% change) during the 3 months prior to Screening
• Positive glutamic acid decarboxylase 65 and/or Islet Antigen (IA)-2 auto-antibodies
• Age ≥ 18 years and ≤ 55 years
• HbA1c < 7.5% for the previous two measurements including the measurement taken at Screening (both measurements must occur within 6 months prior to enrollment)
• Body-mass index (BMI) > 18 and < 28 kg/m2
• Willingness to maintain current doses/regimens of vitamins and dietary supplements through the end of the study
• For subjects with reproductive potential, a willingness to use contraceptive measures adequate to prevent the subject or the subject's partner from becoming pregnant during the study. Adequate contraceptive measures include hormonal methods used for two or more cycles prior to Screening (e.g., oral contraceptive pills, contraceptive patch, or contraceptive vaginal ring), double barrier methods (e.g., contraceptive sponge, diaphragm used in conjunction with contraceptive foam or jelly, and condom used in conjunction with contraceptive foam or jelly), intrauterine methods (IUD), sterilization (e.g., tubal ligation or a monogamous relationship with a vasectomized partner), and abstinence.

Exclusion criteria

• Regular training of more than 90 minutes / week
• History or signs of cardiovascular disease, proliferative retinopathy, nephropathy or neuropathy
• Signs of current infection
• Neutropenia
• Anemia
• Clinically significant kidney or liver disease
• Current immunosuppressive treatment or documented immunodeficiency