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OpenTrials
Completed

NCT Number: NCT01038726

Effects of Exercise and Cognitive Training on Cognitive Function in Older Adults

The purpose of this study is to gain a better understanding of the effects of exercise and cognitive training on improving brain function in healthy older adults who may be at risk for developing Alzheimer's Disease.

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Key information

Conditions

Aging Alzheimer Disease Alzheimer's Disease Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Tauopathies

Age range

60 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The Cleveland Clinic

Cleveland, Ohio, 44195, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • First or Second-degree relative of someone with Alzheimer's Disease
  • Not currently engaging in regular exercise
  • Able to undergo an MRI
  • Fluent in English

Exclusion criteria

  • Neurological illnesses/conditions
  • Medical illness/conditions that may affect brain function
  • Any unstable or severe cardiovascular disease or asthmatic condition
  • Severe depressive symptoms
  • Inability to walk unassisted

Treatment and study plan

Exercise training

Other

Aerobic exercise training program designed by the Cardiac Rehabilitation department

Cognitive Training

Other

Based on cognitive training program Brain Fitness®

Flexibility Training

Other

Non-aerobic flexibility training program designed by the Cardiac Rehabilitation department

Educational sessions

Other

DVD-based educational programs on history, art, and literature

Primary outcomes

  1. Brain activation patterns measured by functional MRI

    Time frame: baseline and 12 weeks

Secondary outcomes

  1. Neuropsychological Testing

    Time frame: baseline and 12 weeks

  2. Exercise assessment

    Time frame: baseline and 12 weeks

Sponsors and collaborators

Lead sponsor

The Cleveland Clinic

Other

Collaborators

  • National Institutes of Health (NIH)

Registry information

Official study title

Neural Effects of Exercise, Cognitive, or Combined Training in AD At-Risk Elders

Important dates

Study start
2009
Primary completion
2012
Study completion
2012
First posted
Dec 24, 2009
Registry last updated
Sep 18, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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