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NCT Number: NCT06693141

Effects of Erector Spinae Plane Block and Intrathecal Morphine Administration on Intraoperative Sevoflurane Consumption

In our study, the investigators aimed to compare the intraoperative sevoflurane consumption and postoperative analgesic needs of patients who underwent lumbar disc herniation surgery and received either ESP block or ITM in the preoperative period with a control group.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ankara Etlik City Hospital

Ankara, Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle, 06170, Turkey (Türkiye)

About this study

The amount of volatile anesthetic agents used for anesthesia maintenance can be significantly reduced with potent and long-acting analgesic interventions administered during the preoperative period. Such interventions enable the maintenance of anesthesia with more optimal levels of agents during surgery, providing significant advantages in terms of both patient safety and cost.

Studies have recommended multimodal analgesia approaches involving the Erector Spinae Plane (ESP) block and intrathecal morphine (ITM) injection for various surgical procedures. These two methods, through different mechanisms of action, not only reduce intraoperative anesthetic agent consumption but also play a critical role in postoperative pain management. Although studies have investigated the effects of ESP block and ITM injection on intraoperative volatile anesthetic consumption, there is limited research directly comparing their impacts on volatile anesthetic consumption and postoperative analgesic requirements.

In our study, we aimed to compare the intraoperative sevoflurane consumption and postoperative analgesic needs of patients who underwent lumbar disc herniation surgery and received either ESP block or ITM in the preoperative period with a control group.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged over 18 years
  • Patients receiving general anesthesia
  • Patients with an ASA score of I-II
  • Patients undergoing elective surgery for single-level lumbar disc herniation
  • Patients who provided informed consent after being informed

Exclusion criteria

Patients who did not provide informed consent after being informed

  • Patients over 65 years of age
  • Patients with an ASA score of III or higher
  • Patients with recurrent lumbar disc herniation (LDH)
  • Patients undergoing surgery for multi-level LDH
  • Patients with a body mass index (BMI) of 30 or higher
  • Patients with allergies to morphine or bupivacaine
  • Patients with major cardiac, respiratory, hepatic, renal, neurological, or psychiatric diseases
  • Patients with a history of alcohol or substance abuse
  • Patients with a local infection at the injection site
  • Patients with bleeding diathesis
  • Patients with a history of anticoagulant medication use
  • Patients with contraindications to spinal or regional anesthesia

Treatment and study plan

ESP block

Other

ESP block was applied to the patients.

ITM

Other

ITM was applied to the patients.

Primary outcomes

  1. Intraoperative Sevoflurane consumption

    Time frame: 60 minutes after anesthesia induction

    End-expiratory sevoflurane concentration was monitored every 5 minutes for 60 minutes. The mean sevoflurane concentration in the first 60 minutes was calculated.

Secondary outcomes

  1. Rescue analgesic consumption

    Time frame: 2 hours postoperatively

    When numerical rating scale was 4 or above, rescue analgesic was administered to the patient.

  2. Rescue analgesic consumption

    Time frame: 4 hours postoperatively

    When numerical rating scale was 4 or above, rescue analgesic was administered to the patient.

  3. Rescue analgesic consumption

    Time frame: 8 hours postoperatively

    When numerical rating scale was 4 or above, rescue analgesic was administered to the patient.

  4. Rescue analgesic consumption

    Time frame: 12 hours postoperatively

    When numerical rating scale was 4 or above, rescue analgesic was administered to the patient.

  5. Rescue analgesic consumption

    Time frame: 24 hours postoperatively

    When numerical rating scale was 4 or above, rescue analgesic was administered to the patient.

Sponsors and collaborators

Lead sponsor

Ankara Etlik City Hospital

Other Gov

Registry information

Official study title

Comparison of the Effects of Erector Spinae Plane Block and Intrathecal Morphine Administration on Intraoperative Sevoflurane Consumption in Disc Surgeries

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Nov 18, 2024
Registry last updated
Nov 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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