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Completed

NCT Number: NCT07155421

Effects of Early Cardiopulmonary Rehabilitation in Patients With Acute Decompensated Heart Failure

Acute decompensated heart failure (ADHF) is a severe condition characterized by rapid deterioration of cardiac function, leading to impaired oxygen delivery and multi-organ dysfunction. ADHF often results in reduced physical and respiratory capacity, greater dependence on oxygen support, difficulty performing daily activities, and prolonged hospital stays. In recent years, early exercise-based cardiopulmonary rehabilitation (CPR) has been introduced as part of heart failure management. Evidence suggests that early CPR improves overall health and cardiac function in heart failure patients. However, data regarding its effects in ADHF remain limited. While some studies indicate that early CPR enhances physical function, its impact on respiratory parameters and clinical outcomes is less well established.

Cardiopulmonary rehabilitation is a multidisciplinary program designed to promote physical, psychological, and social recovery in patients with cardiovascular and pulmonary diseases. It includes exercise training, education, psychosocial support, and behavioral strategies. Early CPR specifically aims to improve cardiovascular and respiratory functions in heart failure patients. Initiating CPR in the early phase of ADHF may accelerate recovery, strengthen cardiopulmonary function, shorten hospitalization, and improve quality of life.

This study aims to evaluate the effects of early CPR on functional capacity, hemodynamic parameters, and respiratory parameters in patients with ADHF.

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Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Istanbul University- Cerrahpasa, Cardiology Institute

Istanbul, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients hospitalized with a diagnosis of acute decompensated heart failure
  • Being clinically stable

Exclusion criteria

  • Having diagnosed pulmonary, neurological, renal, liver, gastrointestinal, orthopedic or oncological pathologies
  • Having cardiomyopathy or congestive pericarditis
  • Recent heart surgery in the past 6 months
  • New or suspected thromboembolic event
  • Presence of open wounds, ulcerations or major dermatological diseases in the lower extremities

Treatment and study plan

Early Cardiopulmonary Rehabilitation

Other

An individualized CPR program including positioning, deep breathing exercises (diaphragmatic and segmental breathing exercises), pursed-lip breathing exercises, breathing exercises using incentive spirometry, and progressive mobilization exercises (in-bed range of motion exercises, sitting, standing, and walking exercises)

Routine in-hospital care

Other

Routine in-hospital care for acute decompansated heart failure

Primary outcomes

  1. Functional capacity

    Time frame: At baseline and at hospital discharge, up to 14 days after admission

    It will be evaluated using 6-min walk test according to the guideline of American Thoracic Society

  2. Physical performance

    Time frame: At baseline and at hospital discharge, up to 14 days after admission

    It will evaluated using Short Physical Performance Battery.

Secondary outcomes

  1. Maximum inspiratory and expiratory capacity

    Time frame: At baseline and at hospital discharge, up to 14 days after admission

    It will be evaluated using incentive spirometer.

  2. Hemodynamic responses to exercise

    Time frame: At baseline and at hospital discharge, up to 14 days after admission

    The change in heart rate before and after exercise will be recorded

  3. Hemodynamic responses to exercise

    Time frame: At baseline and at hospital discharge, up to 14 days after admission

    The change in blood pressure before and after exercise will be recorded

  4. Hemodynamic responses to exercise

    Time frame: At baseline and at hospital discharge, up to 14 days after admission

    The change in oxygen saturation before and after exercise will be recorded

  5. Subjective symptom responses to exercise

    Time frame: At baseline and at hospital discharge, up to 14 days after admission

    Subjective symptom responses to exercise will be evaluated by determining changes in the Modified Borg Dyspnea and Fatigue scales before and after exercise.

Sponsors and collaborators

Lead sponsor

Izmir Bakircay University

Other

Collaborators

  • Istanbul University - Cerrahpasa
  • Saglik Bilimleri Universitesi
  • Yeditepe University

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Sep 4, 2025
Registry last updated
Jun 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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