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Completed

NCT Number: NCT00000244

Effects of Dynorphin 1-13 on Heroin Addiction - 1

The purpose of this study is to evaluate the effects of IV dynorphin in humans during acute heroin abstinence, in order to determine that dynorphin suppresses acute opiate withdrawal, reduces opiate craving, and is safe at doses required to produce the above effects.

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Key information

Conditions

Opioid-related Disorders Behavior Behavior, Addictive Chemically-Induced Disorders Compulsive Behavior Impulsive Behavior Mental Disorders Narcotic-Related Disorders Spinocerebellar ataxia 23 Substance Withdrawal Syndrome Substance-Related Disorders

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

U of Minnesota School of Medicine

Minneapolis, Minnesota, 55415, United States

About this study

Randomized double blinded study of the effects of a single IV dose of dynorphin A 1-13 on heroin withdrawal in human opiate addicts

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

opiate addict between the ages of 18-55

Exclusion criteria

Regular abuse of other drugs, unstable medical conditions

Treatment and study plan

Dynorphin 1 - 13

Drug

Primary outcomes

  1. Craving scale

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Effects of Dynorphin 1-13 on Heroin Addiction

Important dates

Study start
1994
Primary completion
1997
Study completion
1997
First posted
Sep 21, 1999
Registry last updated
May 27, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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