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OpenTrials
Completed

NCT Number: NCT04053036

Effects of Drugs on Responses to Brain and Emotional Processes

To study the effects of a psychostimulant on responses to affective touch in individuals with a range of autistic traits

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Key information

Conditions

Autism Spectrum Disorder Child Development Disorders, Pervasive Healthy Mental Disorders Neurodevelopmental Disorders

Age range

21 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

University of Chicago

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI between 19 and 30 (no one under 130 lbs)
  • Smokers smoking less than 25 cigarettes per week
  • Have used ecstasy no more than 40 times with no adverse responses.

Exclusion criteria

  • High blood pressure
  • Any medical condition requiring regular medication
  • Individuals with a current (within the last year) DSM-IV Axis 1 diagnosis
  • Individuals with a history of dependence on stimulant drugs.
  • Women who are pregnant or trying to become pregnant

Treatment and study plan

MDMA

Drug

Participants will be given 1.5mg/kg of MDMA

Placebo oral tablet

Drug

Participants will be given a placebo capsule that will only contain lactose.

Primary outcomes

  1. Change in Responses to Affective Touch

    Time frame: 1.5 hrs after drug or placebo administration.

    Participants will complete an affective touch task during which time they will rate pleasantness of touch on a scale of -10 to +10 using an analog scale. Higher ratings indicate greater pleasantness.

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Registry information

Official study title

Effects of MDMA on Responses to Affective Touch in Individuals With a Range of Autistic Traits

Acronym: MAT

Important dates

Study start
2019
Primary completion
2021
Study completion
2021
First posted
Aug 12, 2019
Registry last updated
Nov 25, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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