Loughborough University
Loughborough, Leicestershire, LE11 3TU, United Kingdom
Completed
NCT Number: NCT04509388
Effects of Drink Composition on the Appearance of Ingested Water in Body Fluids
To determine the effects of amino acids on the rate of water absorption and availability as a precursor fluid for sweat. Young and healthy (male or female) volunteers will take part in three experimental trials. In each trial, volunteers will be given one of two commercially available sports drinks or a commercially available sport drink with added amino acids in a double-blinded, randomised, crossover design. Each drink will be a single 550 mL bolus. All beverages will be labelled with deuterium (D2O). Trials will be compared for temporal accumulation of deuterium in plasma over the course of 60 minutes and in urine (60 min). Whole blood measurements of haemoglobin and haematocrit will also be made and plasma volume changes calculated. It is hypothesised that the amino acid trial will increase the rate of fluid absorption.
Completed
Looking for future studies?
Notify MeKey information
Age range
18 year–50 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Generally fit and healthy (determined by health screen questionnaire)
- Recreationally active (minimum 3 hours of physical activity per week including walking)
Exclusion criteria
- Any cardiovascular, gastrointestinal, renal or acute/chronic health conditions that may influence the outcomes
- Smoking (including vaping)
- BMI of greater than 30 (combined with a body fat percentage greater than 20%) or BMI lower than 17.5
Treatment and study plan
Composition of Sports Drink
OtherThe composition of sport drinks will be manipulated to determine the effect of drink composition on the appearance of ingested water in body fluid.
Primary outcomes
-
Time at which drink absorption rate was maximum (t1)
Time frame: 60 minutes
Determined from D2O values in venous blood samples collected before and after drink ingestion
-
Time at which drink absorption rate returned to 0 (t2)
Time frame: 60 minutes
Determined from D2O values in venous blood samples collected before and after drink ingestion
-
Time at which 50% of drink was absorbed (t1/2)
Time frame: 60 minutes
Determined from D2O values in venous blood samples collected before and after drink ingestion
-
Maximum absorption rate of drink
Time frame: 60 minutes
Determined from D2O values in venous blood samples collected before and after drink ingestion
-
Area under the curve for D2O
Time frame: 60 minutes
Determined from D2O values in venous blood samples collected before and after drink ingestion
Secondary outcomes
-
Plasma volume
Time frame: 60 minutes
Determined from haemoglobin and haematocrit measures in venous blood samples collected before and after drink ingestion
-
Plasma osmolality
Time frame: 60 minutes
Determined from venous blood samples collected before and after drink ingestion
-
Plasma sodium concentration
Time frame: 60 minutes
Determined from venous blood samples collected before and after drink ingestion
-
Plasma potassium concentration
Time frame: 60 minutes
Determined from venous blood samples collected before and after drink ingestion
-
Plasma glucose concentration
Time frame: 60 minutes
Determined from venous blood samples collected before and after drink ingestion
-
Plasma lactate concentration
Time frame: 60 minutes
Determined from venous blood samples collected before and after drink ingestion
-
Plasma creatinine concentration
Time frame: 60 minutes
Determined from venous blood samples collected before and after drink ingestion
-
Plasma amino acid concentration
Time frame: 60 minutes
Determined from venous blood samples collected before and after drink ingestion
-
Urinary D2O concentration
Time frame: 60 minutes
Determined from urine samples collected before and after drink ingestion
-
Urinary specific gravity
Time frame: 60 minutes
Determined from urine samples collected before and after drink ingestion
Sponsors and collaborators
Lead sponsor
Loughborough University
Other
Collaborators
- Entrinsic Beverage Company LLC
Registry information
Important dates
- Study start
- 2020
- Primary completion
- 2020
- Study completion
- 2020
- First posted
- Aug 12, 2020
- Registry last updated
- Feb 15, 2021
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.