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Completed

NCT Number: NCT01075932

Effects of Docosahexaenoic Acid (DHA)-Rich Fish Oil on Cerebral Haemodynamics

DHA has previously been shown to increase regional cerebral blood flow response to tactile stimulation in aged monkeys; modulation of cerebral blood flow in humans has yet to be demonstrated. Given that the brain relies on a constant supply of blood-borne metabolic substrates (e.g. glucose, oxygen), increasing regional cerebral blood flow may also have an impact on cognitive function. The current study aims to investigate the effects of two doses of DHA-rich fish oil on task-related cerebral hemodynamic response and cognitive performance in healthy adults.

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Key information

Conditions

Cerebral Blood Flow Cognitive Function

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Northumbria University

Newcastle upon Tyne, Tyne and Wear, NE1 8ST, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male/Female
  • 18-35 years
  • Healthy
  • No herbal supplements/prescription medications (excl. contraceptive pill)
  • Non smoker
  • Native English speaker

Exclusion criteria

  • consumes oily fish
  • takes omega-3 supplement
  • food allergies to treatment ingredients

Treatment and study plan

DHA-rich fish oil

Dietary Supplement

Either 1 g or 2 g DHA-rich fish oil taken daily for 12 weeks. Participants in the 1 g group will also consume 1 g olive oil placebo capsules per day to maintain double blind.

Placebo

Dietary Supplement

2 g placebo (olive oil) taken daily for 12 weeks

Primary outcomes

  1. Cerebral blood flow

    Time frame: 12 weeks

    Cerebral blood flow will be assessed using Near Infrared Spectroscopy while participants complete a series of cognitive tasks.

Secondary outcomes

  1. Cognitive function

    Time frame: 12 weeks

    Cognitive function will be assessed using a series of tasks that evaluate working memory, attention and executive function.

Sponsors and collaborators

Lead sponsor

Northumbria University

Other

Collaborators

  • Ginsana SA

Registry information

Official study title

The Cognitive And Cerebral Hemodynamic Effects Of DHA-Rich Fish Oil: A Dose-Ranging Study

Important dates

Study start
2009
Primary completion
2009
Study completion
2009
First posted
Feb 25, 2010
Registry last updated
Feb 25, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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