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OpenTrials
Active, Not Recruiting

NCT Number: NCT06716047

Effects of DL-endopeptidase Producing Probiotics on Human Intestinal NOD2 Ligands and Related Functions

We have discovered a type of probiotic that can target activating intestinal NOD2, which is related to a series of human health issues.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Microecological Therapy Probiotic Intervention

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Industrial Avenue 253, canton

Guangzhou, 020, China

About this study

This trial requires the subjects to take probiotics for a certain period of time, and we will collect blood, stool and questionnaires for subsequent testing, efficacy evaluation and safety evaluation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Tend to participate the trial
  • Willing to provide written informed consent

Exclusion criteria

  • Recent use of probiotics, antibiotics, laxatives, or gastrointestinal ulcer medications within the past month.
  • Gastrointestinal symptoms (e.g., constipation, abdominal pain, diarrhea, melena, hematochezia) in the past month.
  • Other conditions considered by researchers for exclusion

Treatment and study plan

Oral administration

Other

Take it directly

Primary outcomes

  1. safty

    Time frame: up to 2 weeks

    Adverse reaction by questionnaire survey

  2. NOD2 activation level

    Time frame: up to 2 weeks

    the level of NOD2 activation by fecal in vitro experiments

Secondary outcomes

  1. Intestinal barrier

    Time frame: up to 2 weeks

    Intestinal Barrier markers

Sponsors and collaborators

Lead sponsor

Zhujiang Hospital

Other

Registry information

Official study title

Effects of DL-endopeptidase Produced by Probiotics on Human Intestinal NOD2 Ligands and Related Functions

Acronym: probiotics

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Dec 4, 2024
Registry last updated
Jan 7, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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