Effects of Dioscorea Yam Gruel on Blood Lipid Profiles in PCI Patients With Coronary Heart Disease

Background:

Percutaneous coronary intervention (PCI) is an important revascularization strategy for coronary heart disease, but it cannot reverse the fundamental pathological process of atherosclerosis. Dyslipidemia is a core risk factor for disease progression. This study aimed to investigate the effects of Dioscorea yam gruel, a traditional Chinese dietary therapy, on blood lipid levels in patients after PCI.

Methods (Brief Outline):

Seventy-two post-PCI patients were randomized 1:1 to control (standard care) or intervention (standard care plus 150 g/day Dioscorea yam gruel for 12 weeks). Lipid profiles were assessed at baseline, 8 weeks, and 12 weeks. Body mass index (BMI) was measured at baseline and 12 weeks.

Inclusion criteria

• Meeting the diagnostic criteria for coronary heart disease (2020 edition)
• Undergoing percutaneous coronary intervention (PCI)
• Aged between 18 and 75 years
• Having been on a stable dose of statin therapy for at least 4 weeks prior to screening
• Being in a stable clinical condition, conscious, providing informed consent, and participating voluntarily

Exclusion criteria

• Low-density lipoprotein cholesterol (LDL-C) level < 70 mg/dL(<1.81mmol/L) at screening
• Complicating with other severe diseases or diseases that affect blood lipid levels, such as malignant tumors, acute cerebrovascular disease, nephrotic syndrome, severe liver disease, Cushing's syndrome, and others
• Pregnancy or lactation
• Concurrently participating in other dietary or exercise intervention programs