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OpenTrials
Completed

NCT Number: NCT01785134

Effects of Different Surgical Methods to Treat Obesity

Obese patients have an increased risk for developing severe metabolic disorders. This risk can only partly be reduced by weight reduction. The investigators have in a pilot study investigated if removal of abdominal fat (visceral) in addition to weight loss has additional beneficial effects on the metabolic profile and weight loss. This study aims to further investigate if removal of abdominal fat (major omentum) leads to beneficial metabolic effects.

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Key information

Conditions

Obesity Body Weight Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Insulin Sensitivity Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Type 2 Diabetes

Age range

18 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Danderyds Hospital, Stockholm, Stockholm County, Sweden

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Body mass index over 40 kg/m2

Body mass index over 35 kg/m2 with obesity associated co-morbidities such as type 2 diabetes and/or additional cardiovascular risk factors -

Exclusion criteria

-

Treatment and study plan

Omentectomy

Procedure

Gastric bypass operation

Procedure

Primary outcomes

  1. Insulin Sensitivity at 2 Years

    Time frame: 2 years postoperative

    Insulin sensitivity measured by hyperinsulinemic euglycemic clamp

Secondary outcomes

  1. Body Composition at Two Years

    Time frame: 2 years postoperative

  2. Blood Pressure at 2 Years

    Time frame: 2 years postoperative

  3. Body Mass Index at 2 Years

    Time frame: 2 years postoperative

  4. Blood Lipids

    Time frame: 2 years postoperative

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Collaborators

  • Region Stockholm
  • The Swedish Research Council

Registry information

Official study title

Metabolic Effects of Different Surgical Methods to Treat Obesity

Acronym: DEOSH

Important dates

Study start
2006
Primary completion
2011
Study completion
2011
First posted
Feb 7, 2013
Registry last updated
Oct 2, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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