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Completed

NCT Number: NCT02093481

Effects of Dietary Fibre on Glucose Metabolism and Satiety

The experimental model is a semi-acute study where the purpose of the study is to evaluate food factors related to colonially derived regulation of glucose metabolism (and related parameters) and satiety in healthy subjects.

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Key information

Conditions

Obesity Body Weight Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Metabolic Syndrome Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

20 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Applied Nutrition and Food Chemistry, Lund Univeristy

Lund, SE, 221 00, Sweden

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Normal fasting blood glucose, BMI 19-25 kg/m2

Exclusion criteria

  • Gastrointestinal diseases or food allergies e.g. lactose-, gluten intolerance, metabolic disorders e.g. diabetes, tobacco/snuff users. Antibiotic or probiotic usage within two weeks, and during study. Vegetarians.

Treatment and study plan

Test meal

Other

reference

Other

Priming

Other

The reference or test meal was eaten 3 days prior to measurements of variables.

No priming

Other

The reference or test meal was eaten 1 days prior to measurements of variables.

Primary outcomes

  1. Blood glucose

    Time frame: Postprandial 0-180 min after breakfast

    The test products are both ingested one day and three days prior to measurements of variables.

  2. Insulin

    Time frame: Postprandial 0-180 min after breakfast

    The test products are both ingested one day and three days prior to measurements of variables.

  3. Appetite hormones

    Time frame: Postprandial 0-180 min after breakfast

    The test products are both ingested one day and three days prior to measurements of variables.

  4. Markers of colonic fermentation and inflammation

    Time frame: Postprandial 0-180 min after breakfast

    The test products are both ingested one day and three days prior to measurements of variables.

Secondary outcomes

  1. Subjective satiety

    Time frame: Postprandial 0-180 min after breakfast

    The measures of hunger, satiety, and desire to eat with the use of a VAS were determined every hour throughout the postprandial testing sessions.

Sponsors and collaborators

Lead sponsor

Lund University

Other

Registry information

Official study title

Intrinsic Indigestible Carbohydrates as Means to Modulate Colonic Events, With Specific Focus on Metabolism and Satiety

Important dates

Study start
2014
Primary completion
2014
Study completion
2014
First posted
Mar 21, 2014
Registry last updated
Jun 26, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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