Center for Clinical Metabolic Research, Herlev-Gentofte Hospital
Hellerup, 2900, Denmark
NCT Number: NCT05953064
This study is an investigator-initiated, randomised, double-blind, placebo-controlled, cross-over human trial investigating the effect of DHA-NAT (C22:6 N-acyl taurine, an endogenous metabolite derived from the omega-3 fatty acid, docosahexaenoic acid) on postprandial plasma triglyceride levels following a high-fat meal.
This study is active but is not currently recruiting participants.
18 year–30 year
Male
Interventional
Not applicable
Hellerup, 2900, Denmark
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Endogenous metabolite of omega-3 fatty acid docosahexaenoic acid
Other names: C22:6 N-acyl taurine
Vehicle control (H2O) for the intervention used in the experimental arm (DHA-NAT).
Time frame: 0-240 minutes
Change in incremental area-under-curve plasma triglyceride
Time frame: 0-240 minutes
Plasma GLP-1 profile
Time frame: 0-240 minutes
Profile of plasma n-acyl taurine species
Time frame: 0-240 minutes
Plasma ApoB48 profile
Time frame: 0-240 minutes
Development during study day recorded by visual analogue scale (VAS), 0-10 cm where 0 = not in agreement with statement and 10 = in agreement with statement.
Time frame: t=240 minutes
Grams consumed of a standard ad libitum meal
Time frame: t=240 minutes
kcal consumed of a standard ad libitum meal
Time frame: 0-240 minutes
total TG, and TG in HDL, LDL and VLDL cholesterol, remnant TG
Time frame: 0-240 minutes
Total fatty acids profile
Time frame: 0-240 minutes
Total cholesterol, HDL, LDL, VLDL, remnant cholesterol
Time frame: 0-240 minutes
Insulin, glucagon and gastric inhibitory polypeptide
Time frame: 0-240 minutes
Total amino acids profile
Time frame: 0-240 minutes
Plasma glucose profile
Time frame: 0-240 minutes
Plasma bile acid profile
Time frame: 0-240 minutes
Cholecystokinin profile
Time frame: 0-240 minutes
Difference in volume from most to least full
Time frame: 0-240 minutes
Plasma acetaminphen profile
Time frame: Up to 24 hours from ingestion of test meal or until first bowel movement if later than 24 hours.
Self-assessment of stool quality by the Bristol Stool Scale (1-7, where 1 = most solid and 7 = least solid)
University Hospital, Gentofte, Copenhagen
Other
Effects of DHA-NAT on Postprandial Lipidaemia in Healthy Male Subjects (FEAST): a Randomised, Double-blind, Placebocontrolled, Crossover Study
Acronym: FEAST
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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