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Completed

NCT Number: NCT02843698

Effects of Dexmedetomidine on Oxygenation and Lung Mechanics in Morbidly Obese Patients Undergoing Bariatric Operations

The study aims to investigate the effect of dexmedetomidine on oxygenation and lung mechanics in morbidly obese patients

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Key information

Conditions

Restrictive Lung Disease

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Cairo University

Cairo, Egypt

About this study

The patients of interest are morbid obese patients scheduled for bariatric surgery. Dexmeditomidine will be infused intraoperatively after induction of anesthesia. lung mechanics (dead space and compliance) as well as oxygenation (PF ratio) will be monitored intraoperatively and postoperatively

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Morbid obese (body mass index > 40) with documented restrictive lung disease scheduled to bariatric operation.

Exclusion criteria

  • Heart failure
  • ِِِِArrhythmia
  • Heart block
  • Severe liver or kidney impairment.

Treatment and study plan

Dexmedetomidine

Drug

Dexmedetomidine infusion was previously reported to improve oxygenation and lung dynamics in patients with obstructive lung diseases. In our study we are going to investigate its effect on oxygenation and lung dynamics in restrictive lung disease

Other names: Precedex

normal saline

Drug

Normal saline

Other names: Saline

Primary outcomes

  1. Oxygenation

    Time frame: 2 hours

    assessed by P/F ratio

Secondary outcomes

  1. Lung mechanics

    Time frame: 2 hours

    lung compliance and dead space

  2. arterial blood pressure

    Time frame: 2 hours

    arterial blood pressure measured in mmHg

  3. plateau airway pressure

    Time frame: 2 hours

    plateau airway pressure measured in cmH2o

  4. heart rate

    Time frame: 2 hours

    number of heart beats per minute

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Effects of Dexmedetomidine on Oxygenation and Lung Mechanics in Morbidly Obese Patients Undergoing Bariatric Operations: A Randomized Controlled Trial

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Jul 26, 2016
Registry last updated
Aug 29, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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