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Completed

NCT Number: NCT04226625

Effects of Desflurane and Propofol During Lung Volume Reduction Surgery

Patients presenting for lung volume reduction are very high risk patients and it is important they receive the best anesthetic available. This study aims to answer which is the best anesthetic for managing such cases.

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Key information

Conditions

Lung Volume Reduction Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Columbia University Irving Medical Center

New York, 10032, United States

About this study

The anesthetic technique for lung volume reduction surgery consists of a thoracic epidural in combination with a general anesthetic. The thoracic epidural is routine for this operation and allows administration of local anesthetics and painkillers in the epidural space which results in profound pain relief in the area of surgery. The epidural is routinely used for pain control during the surgery and after the surgery when the patient is awake.

The general anesthetic used may be a volatile agent (gas for example Desflurane), which is administered through the anesthesia machine, or an intravenous anesthetic agent, which is administered into a vein through an intravenous line as a continuous infusion (example Propofol). The use of an anesthetic agent and an epidural often causes a decrease in blood pressure which is treated with medication. The investigators are comparing the two anesthetic techniques regarding their effect on blood pressure and the amount of medication needed to treat it.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Scheduled to undergo lung volume reduction surgery (LVRS)

Exclusion criteria

  • Does not sign a study consent form

Treatment and study plan

Propofol

Drug

Intravenous administration

Other names: Diprivan

Desflurane

Drug

Volatile administration

Other names: Suprane

Primary outcomes

  1. Time of discontinuation of anesthetic to eye opening

    Time frame: Up to 30 minutes (during procedure)

    Measured in minutes

  2. Time of discontinuation of anesthetic to tidal volume (TV) 300ml

    Time frame: Up to 30 minutes (during procedure)

    Measured in minutes

  3. Time of discontinuation of anesthetic to extubation

    Time frame: Up to 30 minutes (during procedure)

    Measured in minutes

Secondary outcomes

  1. Duration of intensive care unit (ICU) stay

    Time frame: Up to 1 month from procedure

    Measured in days

  2. Duration of hospital stay

    Time frame: Up to 1 month from procedure

    Measured in days

Sponsors and collaborators

Lead sponsor

Columbia University

Other

Registry information

Official study title

A Comparison of the Anesthetic and Hemodynamic Effects of a Volatile Anesthetic (Desflurane) and an Intravenous Anesthetic (Propofol), During Lung Volume Reduction Surgery

Important dates

Study start
2000
Primary completion
2001
Study completion
2002
First posted
Jan 13, 2020
Registry last updated
Jan 13, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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