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Completed

NCT Number: NCT01543386

Effects of Curcumin on Vascular Reactivity

The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk

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Key information

Conditions

Healthy Volunteers (Middle-aged Smokers) Behavior Smoking

Age range

50 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

CHU Clermont-Ferrand

Clermont-Ferrand, 63003, France

About this study

The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 50 to 70 year-old volunteers
  • smokers

Exclusion criteria

  • treated hypertension
  • treated hypercholesterolemia
  • chronic disease
  • vegetarian or other unusual diets
  • chronic alcoholism

Treatment and study plan

curcumin

Drug

The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk

Primary outcomes

  1. Changes in brachial Flow Mediated Dilatation

    Time frame: at Visit 1 (Day 0) and visit 2 (Day3/day5)

Secondary outcomes

  1. Changes in fingertip arterial tonometry

    Time frame: at visit 1 (day 0) and visit 2 (day3/day5)

  2. Modifications of leukocytes transcriptome

    Time frame: at visit 1 (day 0) and visit 2 (day3/day 5)

Sponsors and collaborators

Lead sponsor

University Hospital, Clermont-Ferrand

Other

Collaborators

  • ARDEC Association de Recherche de Développement et d'Enseignement de la Cardiologie
  • Association Régionale de Cardiologie d'Auvergne
  • Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Registry information

Official study title

Effects of Curcumin Loading Dose on Vascular Reactivity of Healthy Middle-aged Smokers

Acronym: CURCUMIN

Important dates

Study start
2012
Primary completion
2012
Study completion
2012
First posted
Mar 5, 2012
Registry last updated
Jul 8, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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