Effects of Cultura Yoghurt in Relation to Transit Time and Digestive Discomfort in Healthy Women and Men

Transit time is the time it takes for a substance to pass through the gut. The major part of the transit is spent in the large bowel is therefore mainly a colonic event. It has been observed that slow transit time is associated with high prevalence of large bowel disorders. The objectives of this study is to:

• determine the effect on mean transit time after 2 weeks intake of a investigational products using radio-opaque sulphate impregnated polyethylene pellets as markers.
• determine effect of investigational products on total symptom score according to Bristol Stool Form (BSF)
• determine effect of investigational products in gastrointestinal symptoms
• determine safety of intake of the investigational products

Inclusion criteria

• Female and Males
• Healthy
• BMI 19-29 at visit 1
• Age 18 and 60 years at visit 1
• Defecation 3-4 times per week or every second to third day (Bristol Stool Form) during the run-in
• Transit time 35 and 72 hours calculated from the abdominal X-ray at visit 3
• Signed written informed consent

Exclusion criteria

• Use of probiotics food or supplements during the study
• Past history of digestive disease
• Previous complicated GI surgery
• Oral use of antimicrobial medication or antimicrobial prophylaxis 4 weeks prior to screening visit
• Use of laxatives (medication or dietary supplements) during the study.
• Pregnant or lactating or wish to become pregnant during the period of the study
• Lack of suitability for participation in the trial, for any reason, as judged by the personnel at KPL Good Food Practice AB