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Completed

NCT Number: NCT06482619

Effects of Creatine and Rehabilitation Programin Athletes With Patellar Tendinopathy

The aim of this study are to analyze the effect of creatine ingestion in pain, histological properties of the tendon, body composition, strength and vertical jump performance in athletes with patellar tendinopathy that follow a physical rehabilitation program that include eccentric exercise combined with stretching and extracorporeal shock wave therapy.

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Key information

Conditions

Creatine Patellar Tendinopathy Wounds and Injuries

Age range

18 year–49 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Universidad Pontificia Comillas

Madrid, Spain

About this study

Nutrition could play an important role in the rehabilitation from sport injuries. This afirmation is based on studies that analyze the impact of different dietary supplements along immobilization periods, stablishing that creatine, leucine and omega-3 fatty acid supplementation could ameliorate muscle loss, while creatine could potentiate the hypertrophy along the rehabilitation process. For this reason, the aim of this study are to analyze the effect of creatine ingestion in pain, histological properties of the tendon, body composition, strength and vertical jump performance in athletes with patellar tendinopathy that follow a physical rehabilitation program that include eccentric exercise combined with stretching and extracorporeal shock wave therapy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Athletes diagnosed with patellar tendinopathy by sport medicine doctor.
  • Age (>18 years and <49 years).
  • To be federated in a sport modality that involves high repetitive impact in the knee; iii) to train more than 3 sessions weekly.
  • Not having undergone knee surgery.
  • Not having undergone any infiltration of analgesics or platelet-rich plasma during the last year.
  • Not intake any sport performance supplement in the previous year;
  • Smoker person.

Exclusion criteria

  • Not being diagnosed with patellar tendinopathy by a doctor
  • Age (<18 years and > 50 years).
  • Involved in a sport modality without high repetitive impacts during sports activity.

Treatment and study plan

creatine supplementation

Dietary Supplement

The supplements were provided in capsules of 1 g of red color not transparent Guinama S.L.U, 0044634, La Pobla de Valbona, Spain) which were prepared with a Capsunorm 2000 semi-automatic manual capsule filling machine (Miranda del Ebro, Spain). Capsules contained creatine monohidrate (Creapure, Crown Sport Nutrition, Arnedo, Spain)

Placebo

Dietary Supplement

The supplements were provided in capsules of 1 g of red color not transparent Guinama S.L.U, 0044634, La Pobla de Valbona, Spain) which were prepared with a Capsunorm 2000 semi-automatic manual capsule filling machine (Miranda del Ebro, Spain). Capsules contained placebo (i.e., sucrose)

Primary outcomes

  1. Pain evaluation

    Time frame: 8-weeks

    For assessing pain, the Victorian Institute for Sports Assessment - Patella (VISA - P), the most widely used patient-reported outcome measure (including symptom severity), was administered . The VISA - P will be scored with a maximum of 100 points and the higher scores indicate better function, and it shows sensible to identify improvements in therapeutic interventions among patients with tendinopathies.

  2. Tendon thickness.

    Time frame: 8-weeks

    Thickness Tendon of the injuried knee/s was analyzed with ultrasound (GE VENUE 40, Portable Ultrasound, CA, USA), and a linear translator. Participants were positioned supine with a 30º knee flexion (using a roller under the knees), reducing the "locking" of the patella in the femur as in full extension. Ultrasound gel was applied and evaluated by placing the probe longitudinally; in pathological tendons it is the only way to determine the distance of the measurement point from the insertion of the tendon. Thus, subsequent measurements were always made from the same point.

Secondary outcomes

  1. Neuromuscular function

    Time frame: 8-weeks

    Participants performed a neuromuscular test battery consisted in measuring vertical jump capacity (i.e., countermovement jump) and knee extension muscle strength muscular strength in a knee extension machine (Selection Leg Extension, Technogym, Cesena, Italy) with a 5 maximum number of repetitions (5-RM)

Sponsors and collaborators

Lead sponsor

Universidad Pontificia Comillas

Other

Collaborators

  • Lavras University
  • Technical University of Madrid
  • Universidad de Córdoba
  • University of Bologna

Registry information

Official study title

Effects of Creatine Supplementation in Combination With a Rehabilitation Program Physical in Athletes With Patellar Tendinopathy

Acronym: CREATINE_TEN

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
Jul 1, 2024
Registry last updated
Jul 1, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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