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OpenTrials
Completed

NCT Number: NCT00631306

Effects of Cranberry Juice on Risk Factors for Cardiovascular Disease

This study is being done to determine if the use of double strength cranberry juice in daily diet will improve endothelial function.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic

Rochester, Minnesota, 55905, United States

About this study

Study participants will be randomized assigned to drink either placebo (a drink that looks and tastes like cranberry juice, but does not contain cranberry juice) or a double strength Ocean Spray light cranberry juice cocktail for four months.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects over the age of 18 years old with known or suspected cardiovascular disease including documented CAD by cardiac catheterization, and multiple cardiovascular risk factors will be included, regardless of severity of endothelial dysfunction or previous history of cardiovascular events.
  • Subjects with no known history of cardiac disease will also be eligible to participate.
  • Subjects must demonstrate endothelial dysfunction via the RH-PAT test (an RH-PAT score of less than 2.0) to continue participating in this study.

Exclusion criteria

  • Patients will be excluded if they have confounding factors including, but not limited to, history of renal or liver failure, or relevant food allergies (cranberries, etc.).

Treatment and study plan

Primary outcomes

  1. The current study was designed to test the hypothesis that the chronic administration of supplementation with double-strength cranberry juice will improve peripheral endothelial dysfunction.

    Time frame: baseline and 4 months post

Secondary outcomes

  1. The current study was also designed to test the acute effect of double-strength cranberry juice on endothelial function.

    Time frame: 45 mins post consumption

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Collaborators

  • Ocean Spray, Inc.

Registry information

Important dates

Study start
2008
Primary completion
2009
Study completion
2010
First posted
Mar 7, 2008
Registry last updated
Aug 12, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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