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NCT Number: NCT06515327

Effects of Corticosteroid Use on Restoration of Spontaneous Circulation in Cardiac Arrest Patients

We aim to investigate the effects of pre-arrest corticosteroid use for any reason on the time of return of spontaneous circulation in patients experiencing witnessed cardiac arrest, either in-hospital or out-of-hospital. Additionally, we plan to study the effects of corticosteroid use on post-ROSC administration of vasoactive agents, required dosage of vasoactive agents and number of vasoactive agents needed in order to reach targeted blood pressure levels.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Etlik City Hospital

Ankara, Yenimahalle, 06170, Turkey (Türkiye)

Location contact

bedriye muge sonmez, ass.prof.

SUB_INVESTIGATOR

elif hamzacebioglu kayisoglu, specalist

CONTACT

[email protected]

+905453300679

elif hamzacebioglu kayisoglu, specialist

SUB_INVESTIGATOR

gulsen akcay, ass. prof

PRINCIPAL_INVESTIGATOR

gulsen akcay, ass. prof.

CONTACT

[email protected]

+905052874949

murat özdemir, specialist

SUB_INVESTIGATOR

tayyar apa, resident

SUB_INVESTIGATOR

About this study

Patients will be collected from Etlik City Hospital Emergency Medicine Department. Patients presenting with witnessed cardiac arrest, either in-hospital or out-of-hospital, will be enrolled in our study.

Inclusion criteria

Age 18 and above Witnessed cardiac arrest

Exclusion criteria

Traumatic cardiac arrest Forensic cases Cardiac arrest secondary to ST-elevation myocardial infarction Patients in whom spontaneous circulation could not be achieved despite cardiopulmonary resuscitation lasting more than 20 minutes Patients with inaccessible past medical records or unknown medication history Patients without identification Unwitnessed cardiac arrest Pregnant patients

Patients will be divided into two groups:

The first group will consist of 23 patients who used corticosteroid medications for any reason before experiencing cardiac arrest.

The second group will consist of 23 patients who did not use corticosteroid medications before cardiac arrest.

Following successful cardiopulmonary resuscitation and restoration of spontaneous circulation, the following parameters will be recorded for both groups: need for vasopressor support, number of vasopressor agents used, maximum dose of vasopressor agent(s) required to maintain mean arterial pressure (MAP) >65 mmHg, duration of stay in intensive care unit/emergency department, mortality rate, length of hospital stay, patients' medical histories, age, and gender.

These parameters will be compared between the corticosteroid-using and non-using groups, and statistical analysis will be conducted to evaluate differences between the two groups

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 18 and above Witnessed cardiac arrest

Exclusion criteria

Traumatic cardiac arrest Forensic cases Cardiac arrest secondary to ST-elevation myocardial infarction Patients in whom spontaneous circulation could not be achieved despite cardiopulmonary resuscitation lasting more than 20 minutes Patients with inaccessible past medical records or unknown medication history Patients without identification Unwitnessed cardiac arrest Pregnant patients

Treatment and study plan

Primary outcomes

  1. return of spontaneous circulation

    Time frame: 20 minutes after cardiac arrest

    patients with return of spontaneous circulation within 20 minutes of cardiopulmonary resuscitation

Study contacts

Contact information is provided by the study sponsor or research team.

elif hamzacebioglu kayisoglu, specialist

CONTACT

[email protected]

+905453300679

gulsen akcay, ass. prof.

CONTACT

[email protected]

+905052874949

Sponsors and collaborators

Lead sponsor

Saglik Bilimleri Universitesi

Other

Collaborators

  • Ankara Etlik City Hospital
  • Etimesgut Military Hospital

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jul 23, 2024
Registry last updated
Jul 23, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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