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OpenTrials
Completed

NCT Number: NCT06510686

Effects of Core Stabilization and Inspiratory Muscle Training in Patients With COPD

In Chronic Obstructive Pulmonary Disease (COPD), a mismatch develops between the respiratory system's demand and the functional capacity of respiratory muscles due to the combination of local and systemic factors increasing the respiratory workload. This results in impaired coordination of muscle groups, leading to muscle dysfunction. Respiratory muscle dysfunction is a significant determinant of life expectancy in COPD. Additionally, respiratory muscles unable to cope with increased workloads lead to impaired respiratory functions and reduced exercise capacity.

It is widely accepted that appropriate training of respiratory muscles can increase their strength, endurance, and their close relationship with lung volume capacities. Besides their role in respiration, respiratory muscles also contribute to postural function and core stabilization. Studies on respiratory muscle training in COPD have primarily focused on inspiratory muscle strength training, neglecting the core stabilization function of respiratory muscles. However, optimal gains in a muscle can only be achieved with training tailored to its functional characteristics. Therefore, a comprehensive training program should be developed considering the multifunctional nature of respiratory muscles. Studies published in healthy individuals and different patient populations demonstrate that core training can improve lung functions. The aim of this study is to compare the effects of inspiratory muscle training and core stabilization training on diaphragm activation, inspiratory muscle strength, functional capacity, respiratory functions, physical activity, and quality of life in individuals with COPD.

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Key information

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sağlık Bilimleri Üniversitesi

Ankara, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Being over 18 years old
  • Having a diagnosis of COPD according to the GOLD criteria and being at stage 3 or lower
  • Not being in an acute exacerbation period and having at least one month since the last exacerbation
  • Being able to walk independently
  • Having sufficient mental capacity to understand the tasks in the study (Mini-Mental Test >24)
  • Being willing to participate in the study

Exclusion criteria

  • Being a stage 4 COPD patient according to the GOLD criteria
  • Having a diagnosis of lung cancer, pulmonary hypertension, and heart failure
  • Being in a COPD exacerbation period
  • Scoring below 24 on the Mini-Mental Test
  • Having any other disease that affects respiratory functions
  • Having undergone pulmonary surgery

Treatment and study plan

İnspiratory muscle training

Other

exercises to strengthen inspiratory muscles

Other names: Normal breath exercises and İnspiratory muscle training

Core training

Other

exercises to strengthen inspiratory and core muscles

Other names: Normal breath exercises and İnspiratory muscle training and Core Stabilization

Primary outcomes

  1. Inspiratory Muscle Strength

    Time frame: 8 weeks

    Maximal Inspiratory Pressure (MIP) (cmH2O),

  2. Inspiratory Muscle Activation

    Time frame: 8 weeks

    surface EMG (TLC from FRC (TLC maneuver)(cmH2O)

  3. Respiratory function tests FEV1

    Time frame: 8 weeks

    Spirometry, FEV1 (lt)

  4. Respiratory function tests FVC

    Time frame: 8 weeks

    Spirometry, FVC (lt)

  5. Respiratory function tests PEF

    Time frame: 8 weeks

    Spirometry, PEF (lt/sn)

  6. Respiratory function tests FEV1/FVC

    Time frame: 8 weeks

    Spirometry, FEV1/FVC %

  7. Respiratory function MVV

    Time frame: 8 weeks

    Spirometry, MVV(L/min)

  8. Functional capacity

    Time frame: 8 weeks

    Six Minute Walking Test (6MVT) (m)

  9. Symptoms

    Time frame: 8 weeks

    MMRC Dyspnea Scale (Scores range from 0 to 4)

Secondary outcomes

  1. Physical activity,

    Time frame: 8 week

    IPAQ (MET/minute)

  2. Quality of life Tests

    Time frame: 8 week

    SGRQ (Scores range from 0 to 100)

  3. Core Strength

    Time frame: 8 week

    1 minute sit to stand ( how many times sit and stand during 1 minute)

  4. Core Strength flexion

    Time frame: 8 week

    Mcgill Endurance Tests For Trunk Flexion (sec)

  5. Core Strength extension

    Time frame: 8 week

    Mcgill Endurance Tests For Trunk Extension (sec)

  6. Core Strength side bridge

    Time frame: 8 week

    Mcgill Endurance Tests For Side Bridge (sec)

Sponsors and collaborators

Lead sponsor

Mustafa Ertuğrul Yaşa

Other

Registry information

Official study title

Comparison of the Effects of Core Stabilization and Inspiratory Muscle Training on Diaphragm Activation, Inspiratory Muscle Strength, Functional Capacity, Respiratory Functions, Physical Activity and Quality of Life in Patients With COPD

Acronym: COPD

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jul 19, 2024
Registry last updated
Sep 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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