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Completed

NCT Number: NCT05817487

Effects of COP Exercise and HIIT on Vascular Health in Young Overweight Females

The goal of this study is to determine the effects of high-intensity interval training and crossover point exercise training on vascular health in young overweight women.

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Key information

Conditions

Vascular Diseases Cardiovascular Diseases

Age range

18 year–30 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Beijing Sport University

Beijing, China

About this study

In recent years, improving cardiovascular health through exercise has become a popular research question, however, it is not clear which intensity and modes of exercise bring more benefits. Crossover point(COP) intensity has great medical potential as a personalized exercise intensity that is based on substrate utilization mode, especially in overweight and obese people.On the other hand, several studies have demonstrated that HIIT is an effective method in improving vascular endothelial dysfunction. During our study, we evaluated the vascular health changes in young overweight women who received either COP exercise or HIIT exercise for 10 weeks.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female, 18-30 years old
  • Body mass index (BMI) < 28 kg/m2 and ≥ 24 kg/m2
  • No exercise habit, and no recent new exercise plan
  • No contraindications to exercise

Exclusion criteria

  • Participates had an orthopedic or other condition that limited participation in daily exercise
  • Participates had a history of myocardial infarction, stroke, diabetes mellitus, chronic respiratory disease or cancer
  • Participates had smoking or alcohol behavior

Treatment and study plan

High-Intensity Interval Training (HIIT)

Behavioral

Participants in both the COP and HIIT groups underwent 30 sessions of exercise performed over 10 weeks. The training sessions in the HIIT group involved five high-intensity intervals of 4 minutes each (running or walking on a treadmill) at 85% VO2max interspersed with 3 minutes of low-intensity walking.

crossover point(COP) exercise training

Behavioral

Participants in both the COP and HIIT groups underwent 30 sessions of exercise performed over 10 weeks. The COP exercise training sessions involved 45 minutes of continuous exercise at the COP on a treadmill.

Primary outcomes

  1. brachial-ankle pulse wave velocity (baPWV)

    Time frame: 10 weeks

    The change of baPWV before and after intervention

  2. blood pressure

    Time frame: 10 weeks

    The change of blood pressure before and after intervention

Secondary outcomes

  1. Interleukin 6 (IL-6)

    Time frame: 10 weeks

    The change of IL-6 level before and after intervention

  2. Homocysteine (HCY)

    Time frame: 10 weeks

    The change of HCY level before and after intervention

Sponsors and collaborators

Lead sponsor

Beijing Sport University

Other

Registry information

Official study title

Effects of Crossover Point Exercise and High-intensity Interval Training on Vascular Health in Young Overweight Females

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Apr 18, 2023
Registry last updated
Apr 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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