Skip to main content
OpenTrials
Completed

NCT Number: NCT00338403

Effects of Continuous Airway Pressure on the Ability to Heat and Humidify Air

We hypothesize that continuous positive pressure applied to the airway will decrease the ability of the nose to warm and humidify inspired air compared to zero or negative pressure.

We will use continuous positive airway pressure (CPAP), a device commonly used to treat patients with sleep apnea, to vary the pressure in the airway and determine if increased pressure decreases the ability to warm and humidify inspired air. If our hypothesis is correct, it may explain the reason why CPAP is poorly tolerated in patients with sleep apnea; i.e., less ability to warm and humidify air leading to more nasal mucosal irritation.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Healthy

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Chicago

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Males and females between 18 and 55 years of age.
  • A clinical history suggestive of normal nose and upper airway, other than during a cold.
  • Willingness of the subject to participate in and complete the study, and the ability to understand the purpose of the trial.

Exclusion criteria

  • Physical sign or symptoms suggestive of renal, hepatic or cardiovascular disease.
  • Women of childbearing potential who are pregnant, trying to become pregnant or nursing a child.
  • Subjects treated with systemic steroids during the previous 30 days.
  • Subjects treated with topical (inhaled, intranasal or intraocular) steroids, Nasalcrom or Opticrom during the previous 15 days.
  • Subjects treated with oral antihistamine/decongestants during the previous seven days.
  • Subjects treated with topical (intranasal or intraocular) antihistamine/decongestants during the previous 3 days.
  • Subjects treated with immunotherapy.
  • Subjects on chronic anti-asthma medications.
  • Subjects with polyps in the nose or a significantly displaced septum.
  • Subjects who have incurred an upper respiratory tract infection within 14 days of the start of the study.

Treatment and study plan

Continuous positive airway pressure (CPAP) at -5, 0, 5 and 10 cm of water

Procedure

Primary outcomes

  1. The amount of water evaporated during the last 5 minutes of exposure to cold, dry air

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Collaborators

  • Fisher and Paykel Healthcare

Registry information

Important dates

Study start
2006
Primary completion
2006
Study completion
2006
First posted
Jun 20, 2006
Registry last updated
Sep 5, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.