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Completed

NCT Number: NCT05425407

Effects of Collagen Peptide Supplementation on Muscle and Tendon Damage and Function

The aim of the study is to investigate the acute and short-term effects of collagen peptides (Collagen Peptan) on muscle and connective tissue during an eccentric overload training period. Currently, all studies investigating the effects of post-exercise collagen supplementation did this in the absence of whey proteins, which are part of the standard recommendations for post-exercise recovery. The investigators will therefore investigate whether the combined intake of whey proteins and collagen peptides ensures a better recovery of exercise performance and whether it can prevent or reduce symptoms of muscle and tendon overload during a three-week eccentric overload training period (n = 22).

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Key information

Conditions

Exercise Behavior Healthy Male Subjects Motor Activity

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Exercise Physiology Research Group

Leuven, Vlaams-Brabant, 3001, Belgium

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Sports participation, including general fitness training, between 2 and 5 hours max per week
  • Body mass index between 18.5 and 25

Exclusion criteria

  • Any kind of injury/pathology that is a contra-indication to perform high-intensity exercise - Intake of any medication or nutritional supplement that could impact muscle protein synthesis and/or exercise performance during the period of the study
  • Intake of any whey protein, casein of branched-chain amino acid (BCAA) supplements from 1 month prior to the start of the study
  • Blood donation within 3 months prior to the start of the study
  • Smoking
  • Current participation in another research trial
  • Any other argument to believe that the subject is unlikely to successfully complete the full study

Treatment and study plan

Whey Protein

Dietary Supplement

Daily 45g of whey protein supplementation during a three week eccentric training period

whey protein + collagen peptide

Dietary Supplement

Daily 15g of whey protein and 20g collagen peptide supplementation during a three week eccentric training period

Primary outcomes

  1. Change in countermovement jump performance

    Time frame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)

    Change in jump height when performing a countermovement jump, measured via a force platform

  2. Change in maximal isometric knee-extension force of the right leg

    Time frame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)

    Change in maximal isometric knee-extension force (angle = 45°) of the right leg

  3. Change in anteroposterior thickness of the right patellar tendon

    Time frame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)

    Change in anteroposterior thickness of the right patellar tendon

  4. Change in neovascularization of the right patellar tendon

    Time frame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)

    Neovascularization of the right patellar tendon scored with the Modified Ohberg Score (range 0 - 4; the higher the score, the higher the degree of neovascularization).

Secondary outcomes

  1. Change in pain perception at the muscular level (VAS scale)

    Time frame: Training 1 (day 1 of training intervention) - Training 2 (day 3 of training intervention) - Training 8 (day 9 of training intervention) - Training 17 (day 19 of training intervention) - Posttest (day 22 of training intervention)

    Change in pain perception at the muscular level of the right leg, measured via the Visual Analogue Scale (range 0 - 10; the higher the score, the higher the pain level)

  2. Change in pain perception of the patellar tendon of the right leg (VISA-P)

    Time frame: Pretest - Training 1 (day 1 of training intervention) - Training 17 (day 21 of training intervention) - Posttest (day 22 of training intervention)

    Change in pain perception of the patellar tendon of the right leg, measured via the VISA-P questionnaire (range: 0 - 100; the lower the score, the higher the symptoms of patellar tendon overload)

  3. Change in the blood concentration of creatine kinase

    Time frame: Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)

    Change in blood concentration of creatine kinase (marker of muscle damage)

  4. Change in the blood concentration of Interleukin 6 (IL-6)

    Time frame: Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)

    Change in blood concentration of Interleukin 6 (IL-6; marker of inflammation)

  5. Change in the blood concentration of N-terminal propeptide of type I procollagen (P1NP)

    Time frame: Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)

    Change in blood concentration of N-terminal propeptide of type I procollagen (P1NP; marker of collagen synthesis)

Sponsors and collaborators

Lead sponsor

KU Leuven

Other

Collaborators

  • Rousselot BVBA

Registry information

Official study title

A Randomized Double-blinded Placebo-controlled Study to Evaluate the Effect of Collagen Peptide (Collagen Peptan) Supplementation on Muscle and Tendon Damage, Repair, and Functional Capacity During Exercise Training Overload

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Jun 21, 2022
Registry last updated
Jun 21, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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