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Completed

NCT Number: NCT03321110

Effects of Coenzyme Q10 Supplementation on Oxidative Stress, Antioxidant Capacity, Inflammatory Responses, Fatigue Elimination, and Exercise Performance in Athletes

The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day).

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Key information

Conditions

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chung Shan Medical University

Taichung, 40201, Taiwan

About this study

The long-term high-amount and -intensity exercise training could cause oxidative damage, muscle impairment, inflammation and exercise fatigue to athletes easily. Such above conditions will affect the exercise performances and health of athletes. The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day). Eventually, these results of this study can provide the information for the known to improve the oxidative stress, anti-oxidation and inflammation internal to the bodies of athletes for various competitions. As a consequence, the athletic performances can be further enhanced.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Athletes (soccer and taekwondo players)

Exclusion criteria

  • Antioxidant vitamins users
  • Statins or Aspirin therapy.

Treatment and study plan

Placebo

Other

Placebo (dextrin)

Coenzyme Q10

Dietary Supplement

150 mg or 300 mg

Primary outcomes

  1. malondialdehyde (MDA)

    Time frame: 12 weeks

    MDA (micromol/L) will measure by thiobarbituric acid reacting substance.

Secondary outcomes

  1. Antioxidant capacity

    Time frame: 12 weeks

    Total antioxidant capacity (TAC) was measured by a Trolox equivalent antioxidant capacity assay in serum and erythrocytes.

  2. high sensitivity C-reactive protein (hs-CRP)

    Time frame: 12 weeks

    hs-CRP will measure by immunoturbidimetry.

  3. creatine kinase (CK)

    Time frame: 12 weeks

    serum CK will measure by enzymatic method.

  4. Lactate dehydrogenase (LDH)

    Time frame: 12 weeks

    serum LDH will measure by enzymatic method.

  5. one-repetition maximum (1-RM)

    Time frame: 12 weeks

    1RM measurements will report in kilograms for data analysis.

  6. Glucose

    Time frame: 12 weeks

    mmol/L

  7. HbA1C

    Time frame: 12 weeks

    HbA1C will measure by an automated glycated hemoglobin analyzer

  8. Insulin

    Time frame: 12 weeks

    insulin will measure by an automated chemistry analyzer

Sponsors and collaborators

Lead sponsor

Chung Shan Medical University

Other

Registry information

Official study title

Effects of Coenzyme Q10 Supplementation on Oxidative Stress, Antioxidant Capacity, Inflammatory Responses, Fatigue Elimination, and Exercise Performance in Athletes From Different Sports: Cross-sectional, Interventional, and Follow-up Studies

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Oct 25, 2017
Registry last updated
Mar 23, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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