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Completed

NCT Number: NCT00795249

Effects of Chronic Smoking on Circulating Endothelial and Platelet-derived Microparticle

The investigators hypothesized that circulating EMP is a useful surrogate marker of early stage of endothelial damage. To determine the effects of chronic smoking on circulating EMP, from healthy volunteers who have habit of chronic smoking, peripheral blood is drawn at the time of flow-mediated dilatation (FMD) examination. Spot urine is also collected. Circulating EMPs are counted using flow-cytometry. After 2-week smoking cessation, the measurements were repeated.

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Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Vascular Diseases

Age range

20 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Early Phase 1

Primary location

Kurume University Hospital

Kurume, Fukuoka, 830-0011, Japan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy individuals who have no coronary risk factors

Exclusion criteria

  • hypertension
  • dyslipidemia
  • chronic kidney disease
  • liver dysfunction
  • obesity (BMI>25.0)
  • cerebrovascular disease
  • other severe systemic diseases (cancer, inflammatory diseases, etc)

Treatment and study plan

smoking cessation

Behavioral

After baseline examination, the group is asked to quit smoking for 2 weeks.

Primary outcomes

  1. The number of circulating EMP

    Time frame: 2 weeks

Secondary outcomes

  1. FMD

    Time frame: 2 weeks

Sponsors and collaborators

Lead sponsor

Kurume University

Other

Registry information

Important dates

Study start
2008
Primary completion
2010
Study completion
2010
First posted
Nov 21, 2008
Registry last updated
Jun 23, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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