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Active, Not Recruiting

NCT Number: NCT06960967

Effects of Chestnuts on Postprandial Glycaemic Response

Nut consumption is known to improve health outcomes, such as reducing the risk of chronic diseases like diabetes, cognitive impairment, and cardiovascular diseases. While most research has focused on walnuts and almonds, there is limited information on the health benefits of chestnuts. Chestnuts are unique among tree nuts due to their high starch and fibre content, along with vitamins E and C, minerals (potassium, phosphorus, magnesium), and polyphenols.

Evidence from in vitro and animal studies suggests that chestnuts may positively affect health by regulating the gut microbiome, lowering the glycaemic index, and providing antioxidant benefits. The food industry is also exploring new uses for chestnuts, particularly in gluten-free products, due to their nutritional benefits and good taste. Nonetheless, no research has investigated the health effects of chestnuts in humans. By addressing this gap in the literature, the study may lead to the development of new dietary strategies for improved health outcomes.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Postprandial Glycemia Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Monash University

Melbourne, Victoria, Australia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults 18-65 years old
  • Available to attend two testing sessions at the research facility

Exclusion criteria

  • Allergy to nuts and/or gluten,
  • BMI<18.5 or ≥30 kg/m2,
  • Fasting glucose >5.6 mmol/L, presence of diabetes and/or taking anti-diabetic medication
  • Serious health conditions that may affect participation e.g. liver or thyroid dysfunction, recent major surgery,
  • Smoker,
  • Cardiovascular disease
  • Pregnant or breastfeeding women
  • Presence of implanted cardiac defibrillator

Treatment and study plan

Chestnut meal

Other

Participants will receive an isocaloric baked meal with chestnut flour.

Control meal

Other

Participants will receive an isocaloric baked meal without chestnut flour.

Primary outcomes

  1. Postprandial blood glucose incremental area under the curve (iAUC)

    Time frame: Three hour blood glucose iAUC will be calculated from nine time points (0, 15, 30, 45, 60, 90, 120, 150 and 180 mins) after beginning consumption of the test meal.

    Difference in postprandial blood glucose iAUC

  2. Postprandial plasma insulin incremental area under the curve (iAUC)

    Time frame: Three hour insulin iAUC will be calculated from seven time points (0, 30, 60, 90, 120, 150 and 180 mins) after beginning consumption of the test meal.

    Difference in postprandial plasma insulin iAUC.

Secondary outcomes

  1. Postprandial glucose concentration

    Time frame: Glucose concentration will be measured at nine time points (0, 15, 30, 45, 60, 90, 120, 150 and 180 mins) after beginning consumption of the test meal.

    Difference in postprandial glucose concentration

  2. Postprandial insulin concentration

    Time frame: Insulin concentration will be measured in finger prick blood samples at seven time points (0, 30, 60, 90, 120, 150 and 180 mins) after beginning consumption of the test meal.

    Difference in postprandial insulin concentration

  3. Time to peak glucose

    Time frame: Three hours

    Difference in time to peak glucose

Sponsors and collaborators

Lead sponsor

Monash University

Other

Registry information

Official study title

Postprandial Effects of Chestnuts on Glycaemic Response: a Cross-over Trial in Healthy Adults

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
May 7, 2025
Registry last updated
Mar 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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