Effects of Chardonnay Seed Flour on Vascular Health

Inclusion criteria

• Age >= 18 years old
• Demonstrated endothelial dysfunction (EndoPAT score <= 2) at time of screening.

Exclusion criteria

• Age below 18 or above 80
• Endothelial function greater than 2.0 at baseline
• Hypertension (at screening): any patient with systolic blood pressure (SBP >=170 mmHg or diastolic blood pressure >= 110 mmHg, or hypotension (SBP < 100 mmHg
• Abnormal liver function tests
• Uncontrolled Diabetes Mellitus or the use of metformin for Diabetes Mellitus
• Difficulty swallowing capsules
• Gastrointestinal disease manifesting with symptoms of malabsorption such as celiac disease or Crohn's disease
• Non-English speakers
• Vulnerable populations unable to consent such as prisoners or dependents
• Any surgical or medical condition which might significantly alter the absorption, distribution, metabolism, or excretion of the CSF including, but not limited to, any of the following:

• History of major gastrointestinal tract surgery such as gastrectomy, gastroenterostomy or bowel resection
• Any history of pancreatic injury, pancreatitis or evidence of impaired pancreatic function/injury as indicated by abnormal lipase or amylase
• Evidence of hepatic disease as determined by a history of hepatic encephalopathy, a history of cirrhosis, esophageal varices, or a history of portocaval shunt.
• History of hypersensitivity to any of the study supplement or suspected contraindications to the study supplement.
• History of noncompliance to medical regimens or unwillingness to comply with the study protocol