Effects of Cardiorespiratory Rehabilitation on the Right Ventricle in Pulmonary Hypertension

Clinical improvement has been demonstrated after cardiorespiratory rehabilitation in patients with pulmonary hypertension. Rehabilitation is therefore now part of the recommendations for good practice. However, no data is available to elucidate the mechanism of this improvement: an improvement in myocardial reserve or an improvement in peripheral muscular capacity? The main objective of this study is to evaluate the difference in right ventricular contractile reserve before and after cardiorespiratory rehabilitation during stress ultrasound in pulmonary hypertension in 10 patients with pulmonary hypertension.

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Key information

Conditions

Pulmonary Hypertension Cardiovascular Diseases Hypertension Hypertension, Pulmonary Lung Diseases Respiratory Tract Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hôpital Pasteur

Nice, 06002, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Major patients
Proven pulmonary hypertension: PAPm ≥ 25mmHg, known PH
Group 1,3,4 or 5 of the pulmonary hypertension classification
Clinical stability > 1 month clinically determined by clinician
NYHA II or III class
Signature of informed consent form following appropriate information
Patient affiliated to the Social Security System

Exclusion criteria

Associated left heart disease
Complex congenital heart disease
Acoustic window which does not allow the echocardiography to be performed correctly
Permanent cardiac arrhythmia
NYHA IV class and NYHA I class
Inability to perform at least a minimal effort on an ergometer
Unstabilized acute coronary syndrome
Compensatory heart failure
Disturbances of ventricular rhythm veins, may not be narrowed.
Prevalence of high-risk embolic intracardiac thrombus
Prevalence of high-risk embolic intracardiac thrombus
Preference of a medium to high abundance peericard-like thinning.
Venous thromboembolic venous thromboembolic disease (> 3 months)
Left ventricular ejector obstruction (severe and/or symptomatic)
Persons under guardianship, under curatorship, protected by law
Persons deprived of their liberty
Pregnant and parturient women
Major not able or unable to express consent
Minors
Inability to perform cardiac rehabilitation
Modynamic instability
Follow-up impossible for geographical or psychological reasons
Inadequate command of the French language

Treatment and study plan

Stress echocardiography

Other

A stress echocardiography will be performed in addition to the traditional patient care

Primary outcomes

Improvement of the subpulmonary ITS at effort >20% (presence of a right ventricular contractile reserve) defined by the improvement of the ITS or integral subpulmonary time-speed)

Time frame: 4 months

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Acronym: Rehab-HTP

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2020
First posted: Jan 19, 2018
Registry last updated: Aug 29, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed