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NCT Number: NCT07025616

Effects of Buteyko Breathing Exercise in Children With Uncontrolled Asthma

This randomized controlled trial study aimed to measure the effectiveness of the combination of 4-weeks Buteyko breathing exercises and pharmacological therapy compared with pharmacological therapy alone in children with uncontrolled asthma.

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Key information

Conditions

Breathing Techniques Asthma Asthma Control Level Asthma Patients Asthma in Children Breathing Exercise Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

7 year–17 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Universitas Indonesia, Faculty of Medicine

Jakarta Pusat, Dki Jakarta, 10430, Indonesia

Location contact

Ivan S Wibowo, Medical Doctor

CONTACT

[email protected]

+6285647581213

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children aged 7-17 years
  • Uncontrolled or partially controlled asthma (GINA Symptom Control Tool score > 1)
  • Receive bronchodilator therapy, either oral or inhaler from a pediatrician.
  • Children and parents/care givers agree to participate in the study until the end, and parents/care givers sign the informed consent form.
  • Can understand instructions.

Exclusion criteria

  • Inpatients
  • Have received Buteyko breathing exercises or other breathing exercises.
  • Have congenital heart disease, pneumonia, or other significant and uncontrolled health disorders.
  • Have severe physical disabilities or mental retardation that could potentially prevent the implementation of Buteyko breathing exercises.
  • Have contraindications for spirometry examination

Treatment and study plan

Buteyko

Behavioral

The Buteyko breathing exercise is a method that encourages nasal breathing, reducing breathing volume, and using breath-holding exercises to normalize breathing pattern

Asthma reliever and controller

Drug

Asthma reliever and controller according to GINA (Global Initiative for Asthma) guideline

Primary outcomes

  1. Asthma control

    Time frame: At enrollment and end of fourth-week

    Level of asthma control measured by Asthma Control Questionnaire (ACQ) - Indonesian version.

    Minimum value 0, maximum value 6. Higher score means worse outcome.

Secondary outcomes

  1. Asthma Quality of Life

    Time frame: At enrollment and end of fourth-week

    Measured by Pediatric Asthma Quality of Life Questionnaire standardized version (PAQLQ(S)) - Indonesian version.

    Minimum value 1, maximum value 7. Higher scores means better outcome.

  2. Bronchodilator use

    Time frame: At end of fourth-week

    Bronchodilator use measured by logbook, recorded by caregiver of patients

  3. FEV1

    Time frame: At enrollment and end of fourth-week

    Forced Expiratory Volume in one second reflects degree of airway obstruction. Measured by spirometry.

  4. FVC

    Time frame: At enrollment and end of fourth-week

    Forced Vital Capacity is total volume of air that can forcefully exhale after taking the deepest possible breath. Measured by spirometry.

  5. FEV1/FVC

    Time frame: At enrollment and end of fourth-week

    Ratio of Forced Expiratory Volume in 1 second (FEV₁) to the Forced Vital Capacity (FVC). Measured by spirometry.

  6. PEFR

    Time frame: At enrollment and end of fourth-week

    Peak Expiratory Flow Rate is maximum speed (flow rate) of air that can be blowed out in a single forced breath. Measured by spirometry.

  7. Control Pause

    Time frame: At enrollment and end of fourth-week

    Duration of control pause

Study contacts

Contact information is provided by the study sponsor or research team.

Ivan S Wibowo, Medical Doctor

CONTACT

[email protected]

+6285647581213

Sponsors and collaborators

Lead sponsor

Ivan Sofian Wibowo

Other

Collaborators

  • Dr Cipto Mangunkusumo General Hospital
  • Fakultas Kedokteran Universitas Indonesia

Registry information

Official study title

Effectiveness of Buteyko Breathing Exercise in Children With Uncontrolled Asthma: A Single Blind, Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jun 17, 2025
Registry last updated
Jun 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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