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OpenTrials
Completed

NCT Number: NCT04864184

Effects of Breathing Patterns on Post-prandial Vascular Function

The purpose of this study is investigate the effects of two different breathing styles on postprandial vascular function and oxidative stress markers. Participants will complete 2 breathing conditions in random order.

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Key information

Conditions

Healthy Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Aspiration Respiratory Tract Diseases

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Cardiovascular Physiology Laboratory-Texas State University

San Marcos, Texas, 78666, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male participants ages 18-35 years

Exclusion criteria

  • Infection within the previous 4 weeks
  • Renal disorders
  • Any cardiovascular disorders such as prior myocardial infarction, known coronary artery disease, personal history of stroke, heart failure, cardiac arrhythmias
  • Chronic obstructive pulmonary disease
  • Diabetes
  • Inflammatory bowel disease
  • HIV, rheumatoid arthritis, chronic or other inflammatory conditions
  • Currently taking steroids or other anti-inflammatory medications
  • Current use of nonsteroidal anti-inflammatory drugs
  • Smoking
  • Stage 2 hypertension or higher (systolic BP of 140 mm Hg or higher and/or diastolic BP of 90 mm Hg or higher)
  • Lactose intolerance

Treatment and study plan

Normal physiologic rate breathing

Behavioral

2-minute breathing exercises will be completed every 15 minutes.

Slow breathing

Behavioral

2-minute breathing exercises will be completed every 15 minutes.

Primary outcomes

  1. Change in flow-mediated dilation

    Time frame: At baseline and at again 1, 2, 4 hours post high-fat meal consumption

    Ultrasound-derived images of the brachial artery pre- and post-suprasystolic cuff inflation will yield flow-mediated dilation values. These are indices are endothelium-dependent vasodilation.

  2. Changes in oxidative stress

    Time frame: Once at baseline and again at 1, 2, and 4 hours post high-fat meal consumption.

    Blood draws will be performed and samples will be processed and stored for future biochemical analysis of blood markers indicative of oxidative stress.

Sponsors and collaborators

Lead sponsor

Texas State University

Other

Registry information

Official study title

The Effects of Different Breathing Styles on Post High-Fat Meal Blood Vessel Function

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Apr 28, 2021
Registry last updated
Nov 9, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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