Effects of Brain Network by Simultaneous Dual-mode Stimulation in Subacute Stroke Patients

Repetitive transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) has been used for the modulation of stroke patients' motor function by altering the cortical excitability. Recently, more challenging approaches, such as stimulation of two or more sites or use of dual modality have been studied in stroke patients. In this study, simultaneous stimulation using both rTMS and tDCS (dual-mode stimulation) over bilateral primary motor cortices (M1s) was investigated to compare its modulatory effects with single rTMS stimulation in subacute stroke patients.

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Mental Disorders Motor Disorder Motor Disorders Nervous System Diseases Vascular Diseases

Age range

19 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Investigators assessed each patient's motor function using the Fugl-Meyer Assessment (FMA) score and acquired their resting-state fMRI (rs-fMRI) data at two times: prior to stimulation and 2 months after stimulation. Changes in rs-fMRI network measures were investigated between groups.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

First-ever stroke patients
Subacute stage (less than 4 weeks)
Total Fugl-Meyer Assessment (FMA) score under 84

Exclusion criteria

Major active neurological disease or psychiatric disease
A history of seizure
Metallic implants in their brain

Treatment and study plan

rTMS on ipsilesional M1

Device

tDCS on contralesional M1

Device

Primary outcomes

Neuroimaging Assessment

Time frame: Change from baseline resting-state brain network at 8 weeks after intervention

Resting-state fMRI

Sponsors and collaborators

Lead sponsor

Samsung Medical Center

Other

Registry information

Official study title

Investigation for Individualized Noninvasive Neuromodulation in Neurorehabilitation of Brain Disease: Longitudinal Study

Important dates

Study start: 2014
Primary completion: 2017
Study completion: 2017
First posted: Sep 12, 2017
Registry last updated: Sep 14, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed