Effects of Blood Gas Perturbations

In this study, the effects of blood gas perturbations on neuromuscular function of the diaphragm and lower limbs at rest and during exercise will be investigated.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Healthy

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

healthy
non.smoking
normal lung function
BMI: 18.5-29.9 kg/m2
willing to adhere to study rules

Exclusion criteria

Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
Intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep
Any metal or electronics inside of the body
Presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators
History of seizures or epilepsy
Tattoos on the stimulation sites
Previous enrolment in this study
For women: Pregnancy, breastfeeding, or intention to become pregnant during the study

Treatment and study plan

Gas perturbation

Other

Participants will be breathing a gas mixture of either room air, or hypoxia, or hypercapnia, or a combination of both during 2h. This is followed by an all-out breathing exercise test against a small resistance, while still being in the respective gas condition.

Primary outcomes

Diaphragm contractility

Time frame: Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec

Diaphragm contractility measured before/during/following the gas exposures and the volitional respiratory muscle exercises using transdiaphragmatic and mouth pressure responses.

Other outcomes

Quadriceps contractility

Time frame: Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec.

Quadriceps contractility will be assess before, during and following the gas exposures and respiratory muscle contractions

Study contacts

Contact information is provided by the study sponsor or research team.

Christina M. Spengler, Prof.

CONTACT

[email protected]

+41 44 632 5007

Sponsors and collaborators

Lead sponsor

Swiss Federal Institute of Technology

Other

Registry information

Official study title

Effects of Blood Gas Perturbations on Neuromuscular Function of the Diaphragm and Lower Limbs at Rest and During Exercise.

Important dates

Study start: 2026
Primary completion: 2029
Study completion: 2029
First posted: Jul 14, 2026
Registry last updated: Jul 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Not Yet Recruiting