Effects of Atorvastatin Versus Probucol on Small Dense LDL

The study is a randomized crossover trial comparing the effect of atorvastatin (10 mg/day) and probucol (500 mg/day) for 24 weeks in 30 patients (urinary albumin excretion 0.3-2.0 g/day, and creatinine clearance > 30 ml/min/1.73 m2 or serum creatinine concentration < 2 mg/L). Lipid parameters, mean LDL particle diameter, creatinine clearance, and urinary albumin to creatinine excretion ratio are measured before and during treatment periods. It will be evaluated that, first, whether atorvastatin and probucol significantly reduce serum total cholesterol and LDL cholesterol concentrations, second, whether atorvastatin and probucol significantly increase the LDL particle size, third, whether significant differences in urinary albumin/creatinine excretion ratio and creatinine clearance are observed in both groups during treatment.

Inclusion criteria

• Hyperlipidemic patients with non-diabetic nephropathy

Exclusion criteria

• Endocrinological, hematological or hepatic disease
• Cerebral infarction or hemorrhage
• Homozygous familial hypercholesterolemia
• Uncontrolled hypertension
• Myocardial infarction occurring within the previous 6 months
• Unstable angina
• Diabetic nephropathy
• Abnormal thyroid function
• Receiving steroids or immunosuppressive agents