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NCT Number: NCT02107170

Effects of Anesthetics on Postoperative Cognitive Function of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.

Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities are two kinds of common surgeries in the investigators' hospital. The effects of anesthetic agents on postoperative outcome, especially cognitive function, are not clear. In this study investigators propose to measure postoperative cognitive function and other outcome of patients who are undergoing these two kinds of surgeries, and try to identify whether there is an association between different kinds of anesthetics and postoperative outcome. Investigators will also observe whether changes in plasma levels of VEGF, TGF-1, TNF-α, IL-1β, and IL-6, are associated with postoperative delirium or cognitive change.

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Key information

Conditions

Endovascular Repair of Aortic Aneurysm Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

First Affiliated Hospital, Sun Yat-Sen University

Guangzhou, Guangdong, 510080, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 18-100 years of age
  • Patients presenting for Endovascular repair of aortic aneurysm and endovascular treatment of arteriosclerosis obliterans of lower extremities

Exclusion criteria

  • Patients with pre-existing delirium
  • Inablility to converse

Treatment and study plan

Sevoflurane

Drug

sevoflurane-based general anesthesia

Propofol

Drug

total intravenous anesthesia

Remifentanil

Drug

Primary outcomes

  1. Number of patients with postoperative cognitive dysfunction

    Time frame: 7 days after surgery

Secondary outcomes

  1. Number of patients with postoperative cognitive dysfunction

    Time frame: 3 months after surgery

  2. Changes in plasma levels of VEGF, TGF-1, TNF-α, IL-1β, and IL-6 (a composite outcome measure)

    Time frame: 3 days after surgery

Sponsors and collaborators

Lead sponsor

Tao Zhang

Other

Registry information

Official study title

Comparison of Intravenous Anesthetics and Volatile Anesthetics on Postoperative Cognitive Dysfunction of Patients Undergoing Endovascular Repair of Aortic Aneurysm and Endovascular Treatment of Arteriosclerosis Obliterans of Lower Extremities.

Important dates

Study start
2014
Primary completion
2017
Study completion
2017
First posted
Apr 8, 2014
Registry last updated
Jun 12, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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