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OpenTrials
Completed

NCT Number: NCT04630938

Effects of Anaesthesia on Inflammatory Markers

undertake confidently both open and laparoscopic cholecystectomy. Major types of body injuries surgical or accidental; evoke a temporary, yet predictable systemic inflammatory response caused by hormonal, immunological and metabolic mediators. This inflammatory response is essential for tissue repair and has evolved to maximize the organisms' healing potential. In healthy individuals the inflammatory response to major surgery is well balanced consisting of pro- and anti-inflammatory mediators. The severity of injury, the occurrence of surgical complications and its accompanying level of stress may hinder the balance of the inflammatory response6.

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Key information

Conditions

Inflammatory Response

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Esam A. Hamed

Asyut, 71515, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients aging 18 - 55 years old
  • Patients scheduled for abdominal surgeries
  • Patients with American Society of Anesthesiologists (ASA) I, II physical status

Exclusion criteria

  • Patients' refusal.
  • Critically ill patients.
  • Patients who have contraindications to regional anesthesia.

Treatment and study plan

Morphine sulfate

Drug

intrathecal morphine will be added to anaesthetics

morphine+lidocaine

Drug

local anesthetic will be infused intravenously

Saline

Drug

intravenous saline infusion

Primary outcomes

  1. Visual analogue score

    Time frame: 24 hours

    a scale to measure pain intensity graded from 0 = no pain to 10 = worst pain

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Effects of Anesthetics on Inflammatory Markers in Patients Undergoing Abdominal Surgeries.

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Nov 16, 2020
Registry last updated
Feb 24, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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