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OpenTrials
Completed

NCT Number: NCT07540936

Effects of an Online Yoga Program on Exercise Capacity and Quality of Life in Bronchiectasis Patients

Bronchiectasis is a chronic lung disease characterized by persistent cough, sputum production, shortness of breath, and recurrent infections, which can reduce physical capacity and quality of life. Non-pharmacological interventions, such as exercise-based approaches, are increasingly used to support symptom management in these patients.

This study aimed to evaluate the effects of an eight-week online yoga program on exercise capacity, dyspnea severity, respiratory function, and quality of life in adults with non-cystic fibrosis bronchiectasis. A total of 70 participants were randomly assigned to either a yoga intervention group or a control group. The yoga group participated in supervised online sessions three times per week, including breathing exercises, postures, and relaxation techniques, while the control group received usual care without additional intervention.

Outcomes were assessed at baseline and after eight weeks using pulmonary function tests, the six-minute walk test (6MWT), the Modified Medical Research Council (mMRC) Dyspnea Scale, and the St. George's Respiratory Questionnaire (SGRQ). The study investigated whether yoga could provide a safe and effective complementary approach to improve symptoms and functional capacity in individuals with bronchiectasis.

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Key information

Age range

30 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Istanbul Medipol University, Faculty of Physiotherapy and Rehabilitation

Istanbul, Beykoz, 34810, Turkey (Türkiye)

About this study

Bronchiectasis is a chronic and progressive respiratory disorder characterized by irreversible bronchial dilatation, chronic airway inflammation, and recurrent infections. Patients commonly experience dyspnea, reduced exercise tolerance, fatigue, and impaired quality of life. In addition to pharmacological treatments, pulmonary rehabilitation and exercise-based interventions play an important role in symptom management and functional improvement.

Yoga is a mind-body intervention that integrates breathing exercises (pranayama), physical postures (asanas), and relaxation techniques. Previous studies in chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease, have demonstrated that yoga can improve respiratory muscle function, ventilatory efficiency, and overall well-being. However, evidence regarding its effectiveness in bronchiectasis remains limited.

This randomized controlled trial was conducted to investigate the effects of an eight-week online yoga program on pulmonary function, functional exercise capacity, dyspnea perception, and disease-specific quality of life in patients with non-cystic fibrosis bronchiectasis. Participants were recruited from the Department of Chest Diseases at Istanbul Medipol University between January 2025 and October 2025. Eligible participants were randomly assigned to either a yoga intervention group or a control group using a computer-generated randomization method.

The intervention consisted of 24 supervised online yoga sessions delivered over eight weeks (three sessions per week). Each session included structured breathing exercises, postural practices, and relaxation techniques designed to improve respiratory control, chest expansion, and physical awareness. The control group received standard care without additional intervention during the study period.

Outcome measures included spirometric parameters (FEV1, FVC, FEV1/FVC, PEF, FEF25-75), functional exercise capacity assessed by the six-minute walk test (6MWT), dyspnea severity measured by the Modified Medical Research Council (mMRC) Dyspnea Scale, and health-related quality of life evaluated using the St. George's Respiratory Questionnaire (SGRQ). Assessments were performed at baseline and after the eight-week intervention period.

The study aimed to determine whether yoga could serve as a safe, feasible, and effective complementary intervention to improve functional outcomes and symptom burden in individuals with bronchiectasis, particularly in the context of accessible and remote rehabilitation models.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 30-55 years
  • Diagnosed with non-cystic fibrosis bronchiectasis based on clinical and radiological findings
  • Clinically stable condition
  • No participation in a structured exercise program within the previous 3 months
  • Voluntary agreement to participate

Exclusion criteria

  • Presence of additional respiratory diseases
  • Acute exacerbation or antibiotic use within the previous 4 weeks
  • Physical or cognitive impairments limiting participation
  • Age above 55 years

Treatment and study plan

Yoga Program

Behavioral

The intervention consisted of an eight-week online supervised yoga program including breathing exercises (pranayama), physical postures (asanas), and relaxation techniques. Sessions were conducted three times per week, totaling 24 sessions. The program was designed to improve respiratory control, chest expansion, and overall physical awareness.

Primary outcomes

  1. 6-Minute Walk Distance (6MWT)

    Time frame: Baseline and 8 weeks

    The change in functional exercise capacity assessed by the six-minute walk test (6MWT), measured as the distance (in meters) walked in six minutes.

Secondary outcomes

  1. Dyspnea Severity (mMRC Scale)

    Time frame: Baseline and 8 weeks

    Dyspnea severity assessed using the Modified Medical Research Council (mMRC) Dyspnea Scale (0-4), where higher scores indicate greater breathlessness.

  2. Health-Related Quality of Life (SGRQ)

    Time frame: Baseline and 8 weeks

    Disease-specific quality of life assessed using the St. George's Respiratory Questionnaire (SGRQ), including symptom, activity, impact, and total scores (0-100 scale, higher scores indicate worse quality of life).

  3. FEV1

    Time frame: Baseline and 8 weeks

    Forced Expiratory Volume in 1 Second (FEV1), Pulmonary function assessed as forced expiratory volume in one second (FEV1) using spirometry.

  4. FVC

    Time frame: Baseline and 8 weeks

    Forced Vital Capacity (FVC), Pulmonary function assessed as forced vital capacity (FVC) using spirometry.

  5. FEV1/FVC

    Time frame: Baseline and 8 weeks

    FEV1/FVC Ratio, Pulmonary function assessed as the ratio of FEV1 to FVC using spirometry.

  6. PEF

    Time frame: Baseline and 8 weeks

    Peak Expiratory Flow (PEF), Pulmonary function assessed as peak expiratory flow (PEF) using spirometry.

  7. FEF25-75

    Time frame: Baseline and 8 weeks

    Forced Expiratory Flow (FEF25-75), Pulmonary function assessed as forced expiratory flow between 25% and 75% of FVC (FEF25-75) using spirometry.

Sponsors and collaborators

Lead sponsor

Istanbul Medipol University Hospital

Other

Registry information

Official study title

Effects of an Eight-Week Online Yoga Program on Pulmonary Function, Exercise Capacity, Dyspnea, and Quality of Life in Patients With Non-Cystic Fibrosis Bronchiectasis: A Randomized Controlled Trial

Acronym: YOGA-BR

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Apr 21, 2026
Registry last updated
Apr 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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