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OpenTrials
Completed

NCT Number: NCT01119989

Effects of an Amino-acid Supplement on Hepatic Lipid Metabolism

10 healthy male volunteers will be studied after

* a 6 day weight maintenance, balanced diet * a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day * a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day and 20g amino-acids per day At the end of each 6 days period, the following measurements will be obtained * intrahepatic lipids (1H-MRS) * metabolic effects of fructose ingestion (measurement of substrate oxidation, gluconeogenesis from fructose, palmitate synthesis from fructose, plasma VLDL-kinetics)

This is a randomized, double blinded study

Completed

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Key information

Conditions

Metabolic Syndrome Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Centre Hospitalier Universitaire Vaudois

Lausanne, Canton of Vaud, CH-1011, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 18-30 years
  • sex: males
  • BMI between 19 and 25 kg/m2
  • less than 3 30min- exercise session/week

Exclusion criteria

  • smokers
  • alcohol consumption more than 50g/week
  • consumption of drugs
  • history of diabetes in first degree relatives
  • presence of ferro-magnetic prosthesis, cardiac pacemakers, or any contra-indication to NMR

Treatment and study plan

Fructose+maltodextrin placebo

Dietary Supplement

amino-acid + fructose

Dietary Supplement

Primary outcomes

  1. intrahepatic lipids

    Time frame: after 6 days on each controlled diet

Secondary outcomes

  1. 13C palmitate synthesis

    Time frame: after 6 days on each controlled diet

Sponsors and collaborators

Lead sponsor

University of Lausanne

Other

Collaborators

  • University of Bern

Registry information

Official study title

Effects of a Supplementation With Amino-acids on Hepatic Lipid Metabolism

Acronym: AMINOFRUCT

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
May 10, 2010
Registry last updated
May 4, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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