Effects of Allogenic Umbilical Cord-Derived Mesenchymal Stem Cells on Patients With Rotator Cuff Disease

The Shoulder Pain and Disability Index (SPADI) is a self-administered questionnaire that consists of two dimensions, one for pain and the other for functional activities. The pain dimension consists of five questions regarding the severity of an individual's pain. Functional activities are assessed with eight questions designed to measure the degree of difficulty an individual has with various activities of daily living that require upper-extremity use. The minimum value is 0 and the maximum value is 10. "0" means no pain and "10" means the worst pain imaginable in the pain section. "0" means no difficulty and "10" means so difficult it requires help in the pain section.

The Constant score assesses pain, function, ROM, and strength. Pain is allotted a maximum of 15 points, activities of daily living (function)20 points, ROM 40 points, and strength 25 points. The component scores are summated to achieve a maximum possible total score of 100.

Using a ruler, the score is determined by measuring the distance (mm) on the 100mm line between the "no pain" anchor and the patient's mark, providing a range of scores from 0-100. A higher score indicates greater pain intensity.

When tendon regeneration is identified in the lesion area through arthroscopic examination, a tissue sample approximately 2 mm in diameter is collected from the regenerated site and evaluated using the modified Astrom & Movin scoring system.

The evaluation method consists of seven assessment variables(Fiber structure, Fiber arrangement, Rounding of the nuclei, Variations in cellularity, Increased vascularity, Decreased stainability, Hyalinization), each scored on a scale from 0 to 3, with 0 indicating normal and 3 representing the most severe abnormality. The scores are summed to calculate the tendon degeneration score, which ranges from 0 to 21. A score closer to 0 indicates normal tendon condition, while a score closer to 21 reflects severe degenerative changes.

STR analysis at post-injection

Using a ruler, the score is determined by measuring the distance (mm) on the 100mm line between the "no pain" anchor and the patient's mark, providing a range of scores from 0-100. A higher score indicates greater pain intensity.

The strength the supraspinatus, infraspinatus,and subscapularis was measured using a handheld electronic scale

To determine the overall safety of Autologous Adipose Tissue Derived Mesenchymal Stem Cells carrier using pulse rate

To determine the overall safety of Autologous Adipose Tissue Derived Mesenchymal Stem Cells carrier using blood pressure

The measures are composite.

The total dosage of rescue medication administered to participants during the study period is measured to evaluate the amount of medication required to manage symptoms after treatment.

The frequency of rescue medication usage is measured to assess how often participants required additional medication to manage symptoms during the study period.

Blood glucose levels are measured to assess glycemic control and detect hyperglycemia or hypoglycemia.

The ratio of blood urea nitrogen (BUN) to creatinine is measured to evaluate kidney function.

Serum total protein levels are measured to evaluate overall protein status

Serum albumin levels are measured to assess liver function, nutritional status, and oncotic pressure regulation.

Serum total bilirubin levels are measured to evaluate liver function

AST and ALT levels are measured to assess liver function

Serum ALP levels are measured to evaluate liver and bone health.

Serum γ-GTP levels are measured to assess liver function

Serum creatine kinase levels are measured to assess muscle injury

ESR is measured to assess inflammation or detect inflammatory conditions

Serum CRP levels are measured to evaluate acute inflammation

Urine pH is measured to assess acidity or alkalinity of the urine. Lower values indicate increased acidity, while higher values indicate increased alkalinity. Normal range is typically 4.5-8.0.

Urine specific gravity is measured to evaluate urine concentration or dilution. A value closer to 1.000 indicates more diluted urine, while higher values suggest more concentrated urine. protein

Urine protein levels are measured to assess the presence of proteinuria. Normal range is typically negative or <20 mg/dL.

Urine glucose levels are measured to detect glycosuria. Normal range is negative.

Urine bilirubin levels are measured to assess liver function. Normal range is negative.

Urine blood levels are measured to detect hematuria. Normal range is negative

Urine ketone levels are measured to detect ketonuria. Normal range is negative

Microscopic analysis of urine is performed to identify the presence of red blood cells (RBCs), white blood cells (WBCs), crystals, casts, or bacteria, which may indicate infection, inflammation, or other pathological conditions.