Effects of Aerobic Training in End Stage Renal Disease Patients

The investigators raised the hypothesis that exercise training would be associated with improvement in exercise tolerance and VO2 kinetics in hemodialysis patients.

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Key information

Conditions

Kidney Failure, Chronic Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Federal University of Juiz de Fora-Núcleo Interdisciplinar de Estudos e Pesquisas em Nefrologia (NIEPEN)

Juiz de Fora, Minas Gerais, 36036-330, Brazil

About this study

End-stage renal disease (ESRD) is associated with several hemodynamic and peripheral muscle abnormalities which could slow the kinetics of O2 uptake(VO2)and diminished tolerance to incremental exercise. Although previous studies have shown that aerobic training is able to accelerate VO2 kinetics in several disease populations, little is known if these positive findings are also applicable to hemodialysis patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

The sample included end stage renal disease patients undergoing hemodialysis, three times per week totaling 12h weekly, for at least 6 months in the Nephrology Unit at the University Hospital of the Federal University of Juiz de Fora, State of Minas Gerais, Brazil. No patient had been involved in any kind of exercise training in the preceding 6 months

Exclusion criteria

unstable angina;
uncontrolled arrhythmia;
uncompensated heart failure;
uncontrolled hypertension (systolic blood pressure ≥ 200 mmHg and/or diastolic blood pressure ≥ 120 mmHg);
diabetes mellitus;
severe respiratory diseases;
acute infection;
severe renal osteodystrophy;
neurological or musculoskeletal disturbances

Treatment and study plan

Exercise training

Other

Patients included in the exercise group were submitted to intra-dialytic exercise training, 3 times per week for 12 weeks.

Other names: Exercise group

Primary outcomes

Effects of aerobic training during hemodialysis on exercise tolerance and VO2 kinetics in end stage renal disease patients

Time frame: 3 months

Before and after the intervention or control periods, the participants were submitted to an incremental work rate test and, two days apart, to a constant work rate test to the limit of tolerance.

Sponsors and collaborators

Lead sponsor

Federal University of Juiz de Fora

Other

Registry information

Official study title

Effects of Aerobic Training During Hemodialysis on Exercise Tolerance in End Stage Renal Disease Patients

Important dates

Study start: 2008
Primary completion: 2010
Study completion: 2010
First posted: Nov 4, 2010
Registry last updated: Nov 4, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed