Effects of Activity on Diabetes Risk Among Breast Cancer Survivors on Endocrine Therapy (ABIDE)

80 women between the ages of 18-80 years will be recruited for this study. The study design consists of two separate in-person visits to University of Colorado Anschutz Medical Campus or Colorado State University. The study consists of glucose testing, a body composition scan, exercise testing, and a two-week period of free living activity monitoring.

Inclusion criteria

• Female
• diagnosed with breast cancer
• age 18-80 years
• Completed surgery, chemo- and/or radiation therapy
• Prescribed aromatase inhibitor or SERM for at least one year from the time of screening

Exclusion criteria

• Age < 18 or > 80
• Type 1 diabetes
• Type 2 diabetes
• Prescribed anti-hyperglycemic medication, insulin, or sulfonylurea.
• Pregnant, breastfeeding or planning to become pregnant in next 2 months
• Have absolute contraindications to exercise testing which are:

• Unstable angina
• Recent myocardial infarction, cardiac surgery, or vascular surgery (<3 months)
• Uncontrolled high blood pressure
• Heart failure
• Peripheral artery disease (based on report of symptomatic claudication)
• Hepatic or renal disease
• Severe arthritis or mobility impairment that would interfere with exercise testing
• Suspected cognitive impairment that would prevent understanding or comprehension of study procedures.