Completed

NCT Number: NCT07278245

Effects of Active Upper-Limb Exoskeleton Training in Simulated Hyper-Gravity on Fine Motor Performance, Brain-Muscle Connectivity, Cardiovascular System and Stress Responses in Real Hyper-Gravity

The aim of the study presented here is to assess the effects of exoskeleton training on performance in a real hypergravity situation. In particular, it will analyze fine motor control, autonomic nervous system regulation and metabolic responses. To this end, the study will compare two groups during a pointing exercise in a centrifuge (hypergravity). One group will have been trained to do this exercise using an exoskeleton, while the other will have been familiarized with the task without the exoskeleton. It will assess whether the exoskeleton can be an effective and accessible training tool for astronauts.

Completed

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Key information

Conditions

Motor Learning and Physiological Adaptation

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medes - Imps

Toulouse, Occitanie, 31400, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Maximum weight of 90 kg
Maximum sitting butt-to-shoulder distance of 70 cm
Certified as healthy by a comprehensive clinical assessment
Normal or corrected to normal vision
Right-handed tested with Edinburgh-Handedness-Inventory-Test (≥6th percentile, on https://www.brainmapping.org/shared/Edinburgh.php)
Non smokers
No alcohol or drug dependence, no medical treatment on a regular basis
Affiliated to a Social Security system and, for non-French resident, holding a European Health Insurance Card (EHIC) or a Global Health Insurance Card (GHIC).
Free of any engagement during the study
Test subjects must be able to understand and speak English
Who agreed to take part in the study and signed the informed consent

Exclusion criteria

Left-handed tested with Edinburgh-Handedness-Inventory-Test (<6th percentile)
Subjects with experience in experiments on a short arm human centrifuge or under real hyper-gravity
Non-tolerance to the centrifugation
Any history or presence of clinically relevant chronic disease
Refusal to give permission to contact his general practitioner,
Subject who, in the judgment of the investigator, is likely to be non-compliant during the study, or unable to cooperate because of a language problem or poor mental development,
Subject in the exclusion period of a clinical research,
Subject who has received more than 6000 Euros within 12 months for being a research subject,
Subject who cannot be contacted in case of emergency,
Vulnerable people according to law "Code de la Santé Publique" (L1121-5 to L1121-8)

Treatment and study plan

Training with an exoskeleton

Other

Training to perform an aiming task under simulated hypergravity via an exoskeleton

Primary outcomes

Task performance (movement accuracy)

Time frame: From familiarisation sessions (Day 1 to Day 4) to testing day at Day 5.

Task performance (movement accuracy) is defined as the difference between the position touched on the screen and the position of the displayed target.

The participants will be required to perform an aiming movement task using their right arm, directed toward a target.The participants will need to point to the center of the displayed target.

Sponsors and collaborators

Lead sponsor

Centre National d'Etudes Spatiales

Other Gov

Collaborators

MEDES Institut de Médecine et de Physiologie Spatiales, Toulouse

Registry information

Official study title

Effects of Active Upper-Limb Exoskeleton Training in Simulated Hyper-Gravity on Fine Motor Performance, Brain-Muscle Connectivity, Cardiovascular System and Stress Responses in Real Hyper-Gravity: the EGOS Pilot Study.

Acronym: EGOS

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2026
First posted: Dec 12, 2025
Registry last updated: Feb 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.