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Completed

NCT Number: NCT01963507

Effects of a Resistance Training Period on Blood Pressure of Hypertensive Elderlies: Influence of the Polymorphism of the Angiotensin Converting Enzyme

The study aimed to evaluate the chronic effects of resistance training on blood pressure and biochemical exams in hypertensive elderlies and the influence of the polymorphism of the angiotensin converting enzyme in these response.

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Key information

Conditions

Hypertension Cardiovascular Diseases Vascular Diseases

Age range

60 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UNIMED

Santos, São Paulo, Brazil

About this study

To investigate the chronic effects of resistance training on blood pressure and biochemical exams in elderly, 135 hypertensive elderlies were divided into 2 groups: trained and control. The trained group was submitted to a resistance training period. Before the 16 weeks ACE gene was genotyped (PCR). Before and after 16 weeks, blood pressure (ambulatory), HDL-cholesterol, Total cholesterol, Glycemia, Triacylglycerol (colorimetric assay) and plasminogen activator inhibition (PAI-1), intercellular adhesion molecule (ICAM-1), vascular endothelial cell adhesion molecule (VCAM-1), Adiponectin, tumor necrosis factor alpha (TNF-alpha), C Reactive Protein, Angiotensin II, Angiotensin Converting Enzyme, Angiotensin 1-7, (ELISA assay) were measured.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Hypertensives
  • Age 60 to 85 years
  • Nonactive

Exclusion criteria

  • Orthopedic problems or other problem that prevented the exercises
  • Change in drug treatment during protocol
  • Absence in more than 25% of the exercise sessions

Treatment and study plan

Resistance training

Behavioral

Resistance training performed three times at week for 16 weeks, in 8 exercises for the main muscles, the protocol of 3 sets of 10 repetitions with intensity of 50% of 1 maximum repetition (MR).

Primary outcomes

  1. Blood Pressure

    Time frame: 16 weeks

    Blood pressure was measured by Ambulatorial Monitoring Blood Pressure before and after 16 weeks of intervention.

Secondary outcomes

  1. HDL-cholesterol

    Time frame: 16 weeks

    HDL-cholesterol was analyzed by colorimetric assay, before and after 16 weeks of intervention.

  2. Total Cholesterol

    Time frame: 16 weeks

    Total cholesterol was analyzed by colorimetric assay, before and after 16 weeks of intervention.

  3. Glycemia

    Time frame: 16 weeks

    Glycemia was analyzed by colorimetric assay, before and after 16 weeks of intervention.

  4. Triacylglycerol

    Time frame: 16 weeks

    Triacylglycerol was analyzed by colorimetric assay, before and after 16 weeks of intervention.

  5. PAI-1

    Time frame: 16 weeks

    PAI-1 was analyzed by ELISA assay, before and after 16 weeks of intervention.

  6. ICAM-1

    Time frame: 16 weeks

    ICAM-1 was analyzed by ELISA assay, before and after 16 weeks of intervention.

  7. VCAM-1

    Time frame: 16 weeks

    VCAM-1 was analyzed by ELISA assay, before and after 16 weeks of intervention.

  8. Adiponectin

    Time frame: 16 weeks

    Adiponectin was analyzed by ELISA assay, before and after 16 weeks of intervention.

  9. TNF alpha

    Time frame: 16 weeks

    TNF alpha was analyzed by ELISA assay, before and after 16 weeks of intervention.

  10. C Reactive Protein

    Time frame: 16 weeks

    C Reactive Protein was analyzed by ELISA assay, before and after 16 weeks of intervention.

  11. Angiotensin II

    Time frame: 16 weeks

    Angiotensin II was analyzed by ELISA assay, before and after 16 weeks of intervention.

  12. Angiotensin Converting Enzyme

    Time frame: 16 weeks

    Angiotensin Converting Enzyme was analyzed by ELISA assay, before and after 16 weeks of intervention.

  13. Angiotensin 1-7

    Time frame: 16 weeks

    Angiotensin 1-7 was analyzed by ELISA assay, before and after 16 weeks of intervention.

Sponsors and collaborators

Lead sponsor

Federal University of São Paulo

Other

Collaborators

  • Fundação de Amparo à Pesquisa do Estado de São Paulo

Registry information

Important dates

Study start
2010
Primary completion
2013
Study completion
2013
First posted
Oct 16, 2013
Registry last updated
Oct 16, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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