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NCT Number: NCT07161050

Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing

This study will investigate the effects of a very-low-nicotine cigarette (VLNC) standard, e-cigarette price, and illegal cigarette price on illegal product purchasing and alternative product use in a virtual marketplace.

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Key information

Age range

21 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Fralin Biomedical Research Institute at Virginia Tech Carilion

Roanoke, Virginia, 24016, United States

Location status: Recruiting

Location contact

Kirstin Gatchalian

CONTACT

[email protected]

540-526-2071

Roberta Freitas-Lemos, PhD

PRINCIPAL_INVESTIGATOR

About this study

This experiment will examine the effects of a VLNC standard, electronic cigarette price, and illegal cigarette price on illegal cigarette purchasing. Exclusive cigarette smokers and dual cigarette/nicotine vaping product (NVP) users, stratified by age, will complete multiple scenarios in the legal Experimental Tobacco Marketplace. The investigators will examine the effects of a VLNC standard, predicted to promote illegal purchasing. In the NNC conditions, participants' preferred normal nicotine content (NNC) cigarettes, NVPs, and a variety of other products will be available in the ETM, and preferred NNC cigarettes will also be available in the illegal marketplace. In the VLNC standard conditions, a ban will permit only VLNCs legally in the ETM, but preferred NNC cigarettes will continue to be available illegal marketplace. In this experiment, which will be completed in the lab, we will test three levels of NVP prices and three levels of illegal cigarette prices in scenarios under a VLNC standard or NNC condition. This study will involve a total of three sessions, including an assessment session, an ETM session, and a follow-up phone call.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Provide informed consent Be at least 21 years of age or older Provide a breath sample for measuring carbon monoxide (CO ≥ 8 ppm) Stable tobacco use patterns for at least two months

Exclusion criteria

For exclusive cigarette smokers:

Smoke at least 10 cigarettes daily and do not use NVPs regularly (no more than 9 times in the last month).

For dual cigarette/NVP users:

Smoke at least 10 cigarettes daily and use NVPs at least 3 times in a week (report use of closed nicotine salt system)

For both groups:

Have plans to move out of the area Have a serious or unstable physical or mental health condition Taking a tobacco cessation medication or medication that interferes with nicotine metabolism, motivation or reinforcement Report concrete, immediate plans to alter/quit using their usual nicotine products at the beginning of the study Being pregnant or lactating

Treatment and study plan

Nicotine Content

Behavioral

In the full nicotine conditions, participants' preferred cigarettes and NVP products will be available in the LETM and preferred cigarettes will be available in the iETM. In the low nicotine conditions, a ban will permit only VLNCs in the LETM and preferred cigarettes will be available in the iETM.

Other names: very-low nicotine standard

Illegal cigarette price

Behavioral

At each level of nicotine content, we will manipulate the price of illegal cigarettes (1xMP, 1.5x MP, 2x MP). MP is market price.

E-cigarette price

Behavioral

At each level of nicotine content and illegal cigarette price, we will manipulate the price of e-cigarettes (1xMP, 1.5x MP, 2x MP). MP is the market price.

Primary outcomes

  1. Percent of budget allocated to each product category (eg, legal cigarettes, e-cigarettes, illegal cigarettes, etc) in the marketplace

    Time frame: 1 day

    The investigators will measure the percent of each partcipants' study budget spent on products from each category (eg, legal cigarettes, e-cigarettes, illegal cigarettes, etc) in the marketplace

Study contacts

Contact information is provided by the study sponsor or research team.

Kirstin Gatchalian

CONTACT

[email protected]

540-526-2071

Madeleine Mason, PhD

CONTACT

[email protected]

540-526-2114

Sponsors and collaborators

Lead sponsor

Virginia Polytechnic Institute and State University

Other

Collaborators

  • Medical University of South Carolina
  • National Cancer Institute (NCI)

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Sep 8, 2025
Registry last updated
Jan 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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