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NCT Number: NCT04447391

Effects of a 12-week Combined Exercise Program on Ghrelins in Obese Adolescent Girls

This study aimed to explore the effects of a 12-week combined exercise on ghrelin O acyl transferase, acylated ghrelin and desacylated ghrelin levels in obese girls.

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Key information

Conditions

Ghrelin

Age range

16 year–18 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Pusan National University Yangsan Hospital

Yangsan, Gyeungsangnam-do, 50612, South Korea

About this study

Little is known about on ghrelin O acyl transferase (GOAT), acylated ghrelin (AG) and desacylated ghrelin (DAG) levels during long-term exercise in adolescent population. Our previous study showed that combined exercise program in overweight children increases DAG with unchanged AG. This study aimed to explore the effects of a 12-week combined exercise on GOAT, AG, and DAG in obese girls.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • girls between 16 and 18 years
  • being classified as being overweight or obese defined with the 85th percentile of body mass index or above based on the 2007 growth chart for Korean children aged 2-18 years.
  • After consultation with a physician, they were required to be considered physically healthy enough to engage in regular exercise after school.

Exclusion criteria

  • participation in any weight-management programme in the past 6 months
  • engagement in other exercise programs except for regular physical education at school
  • smoking
  • amenorrhea for consecutive 2 months or more
  • being treated for hereditary diseases, mental disorder, hypertension, diabetes mellitus, or musculoskeletal impairments
  • taking any medication or supplements for weight control

Treatment and study plan

Combined exercise program

Other

Combined exercise programme, consisting of warm-up, aerobic exercise, resistance training, and cool-down, 3 days a week after school for 50 minutes from 17;30 under supervision by a trainer plus 300 kcal deficit diet

Control

Other

300 kcal deficit diet only

Primary outcomes

  1. body fat percent

    Time frame: Change from baseline body fat percent at 12 weeks

    Changes in body fat percent during 12 weeks

  2. acylated ghrelin

    Time frame: Change from concentrations of baseline acylated ghrelin at 12 weeks

    Changes in concentrations of acylated ghrelin during 12 weeks

  3. desacylated ghrelin

    Time frame: Change from concentrations of baseline desacylated ghrelin at 12 weeks

    Changes in concentrations of desacylated ghrelin during 12 weeks

Secondary outcomes

  1. ghrelin O acyl transferase

    Time frame: Change from baseline concentrations of ghrelin O acyl transferase at 12 weeks

    Changes in concentrations of ghrelin O acyl transferase during 12 weeks

Sponsors and collaborators

Lead sponsor

Pusan National University Yangsan Hospital

Other

Registry information

Official study title

Effects of a 12-week Combined Exercise Program on Acylated and Desacyl Ghrelin, and Ghrelin O Acyl Transferase in Obese Adolescent Girls

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Jun 25, 2020
Registry last updated
Jun 26, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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