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Completed

NCT Number: NCT07372209

Effects and Safety of Oliceridine in Anesthesia Induction:A Randomised Controlled Trial

to investigate whether oliceridine is safe and effective for induction of anesthesia by comparing henodynamic changes before and after endotracheal intubation with sufentanil

Completed

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Key information

Conditions

Gynecological Laparoscopic Surgery General Anesthetic Intubation

Age range

18 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Tangshan Maternal and Child Health Hospital

Tangshan, Hebei, 063000, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-65 years;
  • American Society of Anesthesiologists (ASA) physical status I-II;
  • Elective gynecologic laparoscopic surgery;
  • Expected operative time 60-180 minutes;

Exclusion criteria

  • Severe cardiovascular instability (e.g., acute decompensated heart failure, acute myocardial infarction, or life-threatening arrhythmia);
  • Uncontrolled hypertension;
  • Severe renal or hepatic dysfunction;
  • Severe mental disorder or psychiatric illness;
  • Known allergy or hypersensitivity to opioids;
  • History of alcohol abuse or opioid addiction;
  • Anticipated difficult airway;
  • Pregnancy or lactation;

Treatment and study plan

Oliceridine

Drug

Oliceridine is diluted to a 1mg/kg injection solution

Sufentanil

Drug

sufentanil is diluted to a 5μg/ml injection solution

Primary outcomes

  1. blood pressure

    Time frame: baseline, at the moment of intubation, right after intubation, 1 minute、3 minutes, and 5 minutes after intubation

  2. heart beat

    Time frame: baseline, at the moment of intubation, right after intubation, 1 minute、3 minutes, and 5 minutes after intubation

Secondary outcomes

  1. adverse reactions

    Time frame: from the administration of sufentanil or oliceridine until discharge from the post-anesthesia care unit (PACU)

Sponsors and collaborators

Lead sponsor

Tangshan Maternal and Child Health Hospital

Other

Registry information

Official study title

Study of Effects and Underlying Mechanisms of Analgesic Drugs on Inflammatory Pathways and Immune Function in Patients With Endometrial Cancer

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jan 28, 2026
Registry last updated
Jan 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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