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Completed

NCT Number: NCT04515563

Effectiveness of Walking Exercise in Improving Cognitive Function in Older Adults With Mild Cognitive Impairment

The increasing prevalence of mild cognitive impairment (MCI) in our rapidly aging population prompts the need for devising effective interventions to prevent the onset of cognitive impairment and delay its progression to dementia. The benefits of aerobic exercise on the cognitive function in older adults with MCI are well-documented. However, exercise protocols and outcome measurement tools in the current literature are highly heterogeneous. It is therefore imperative to develop standard exercise prescription protocol for the MCI population or to examine the effectiveness of the existing, well-established exercise guidelines. The World Health Organization (WHO) recommends adults (18 - 64 years of age) and older adults (65 years and older) to perform 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic physical activity per week to improve cardiorespiratory and muscular fitness, bone health, and reduce the risk of non-communicable diseases and depression. Nonetheless, few studies have determined the effectiveness of the WHO Global Recommendations on Physical Activity for Health guideline in improving cognitive function in older adults with MCI. This study thus aims to evaluate the effectiveness of the WHO Physical Activity Recommendations in improving cognitive function in older adults with MCI. In 2017, the American Academy of Neurology (AAN) updated the Practice Guideline for Mild Cognitive Impairment, in which they recommended patients diagnosed with MCI to perform exercise at least twice a week for at least 6 months to gain cognitive benefits. This recommendation was based on two class-II studies, in which a 6-month twice-a-week 90-minute multicomponent exercise program helped maintain global cognition, and selective attention improved significantly following a 6-month twice-a-week 60-minute multicomponent exercise program. While they provided pivotal insights into clinical practice, there were several limitations for these two studies. For instance, in the study conducted by Nagamatsu et al., only female subjects were recruited, and therefore lead to low generalizability. These two studies focused on multi-component exercise intervention which included resistance training, aerobic training, and balance training, and the duration of each component was short (around 20 - 30 minutes). Studies that focus on single exercise modality with longer session duration are warranted to unveil the efficacy of a certain exercise modality in improving cognitive function. In this study, we will evaluate the effectiveness of aerobic exercise on improving cognitive function in older adults with MCI. We intend to follow the WHO Recommendations, focusing on evaluating the effect of different exercise intensities (moderate versus vigorous) and frequencies (once versus thrice per week) of aerobic exercise on improving the cognitive function in older adults with mild cognitive impairment. In particular, the AAN also suggested that physical activity of at least twice a week is necessary to produce cognitive benefits. We, therefore, aim to investigate whether one session per week would also suffice to improve the cognitive function in older adults with MCI.

Aims: To examine the effectiveness of 12-week WHO Global Recommendations on Physical Activity for Health in practice in improving the cognitive function in older adults with MCI.

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Key information

Conditions

Mild Cognitive Impairment Cognition Disorders Cognitive Dysfunction Mental Disorders Neurocognitive Disorders

Age range

50 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Li Kai Shing Faculty of Medicine

Hong Kong, Southern District

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Older adults aged ≥ 50 years old;
  • Ethnic Chinese;
  • Diagnosed with mild cognitive impairment (MCI) under the Mayo Clinic criteria [8-10]: 1). Subjective complaint about a decline in cognitive function; 2). Total score in the Hong Kong version of the Montreal Cognitive Assessment is below the 7th percentile of the age- and education-corrected normative data of Hong Kong; 3). The decline in cognitive function does not impair daily functioning, as revealed by getting ≥ 2 marks in every item on the Chinese Lawton Instrumental Activities of Daily Living Scale (4-point Scale).

Exclusion criteria

  • Diagnosis of dementia/Alzheimer's disease, or currently using antidementia medication;
  • Incapable of participating in physical exercise with major confounding conditions that are known to affect mobility. Specifically designed questionnaires will be used to screen for exclusion criteria including 1). Cannot walk without assistive device; 2). Any serious somatic condition that prevents walking exercise participation.
  • History of major diseases e.g. cancer, cardio-/cerebrovascular, neurodegenerative and renal diseases;
  • Diagnosis of psychiatric diseases, or currently using psychiatric medication.

Treatment and study plan

Stretching exercise

Behavioral

Control Group

Low-frequency, moderate-intensity walking group

Behavioral

once-a-week walking exercise at moderate intensity

High-frequency, moderate-intensity walking group

Behavioral

thrice-a-week walking exercise at moderate intensity

Low-frequency, vigorous-intensity walking group

Behavioral

once-a-week walking exercise at vigorous intensity

High-frequency, vigorous-intensity walking group

Behavioral

thrice-a-week walking exercise at vigorous intensity

Primary outcomes

  1. Global cognition-Hong Kong Montreal Cognitive Assessment (HK-MoCA) score

    Time frame: 3-month follow-up

    Age- and education-corrected Hong Kong Montreal Cognitive Assessment (HK-MoCA). The HK-MoCA is a validated assessment for cognitive screening that takes into account different domains of cognition, which will enable the researchers to achieve a better understanding of the global cognitive profile of the individual. Higher score indicates better global cognitive performance.

Secondary outcomes

  1. Objective cognitive score

    Time frame: 3-month follow-up

    The NIH Toolbox Cognitive Function Battery (CFB) will be used to evaluate the various cognitive domains [15]. CFB will be delivered on a tablet computer. A total objective cognitive score will be generated, while a higher score indicates better cognitive performance.

  2. Working memory-Digit Span test

    Time frame: 3-month follow-up

    Working memory will be measured by Digit Span test in paper-pencil based manner. Higher score indicates better cognitive performance.

  3. Working memory-Verbal Fluency Test

    Time frame: 3-month follow-up

    Verbal Fluency Test will be used to measure working memory. Higher score indicates better cognitive performance.

  4. Executive function-Stroop test

    Time frame: 3-month follow-up

    Executive function will be measured by Stroop test. Shorter completion time indicates better performance.

  5. Executive function-Trail Making test

    Time frame: 3-month follow-up

    Executive function will be measured by Trail Making test. Shorter completion time indicates better performance.

  6. Subjective cognitive report

    Time frame: 3-month follow-up

    Cognitive self-report questionnaire (CSQR) will be used to test the subjective cognitive performance. CSQR is validated in HK and consists of 20 questions with overall score ranging from 0-100. Higher score indicates worse self-perception on cognitive performance.

  7. Remission rate-Chinese Abbreviated Mild Cognitive Impairment Test (CAMCI)

    Time frame: 3-month follow-up

    Chinese Abbreviated Mild Cognitive Impairment Test (CAMCI) will be used to classify participants into MCI and non-MCI category. The remission rate will be calculated as remission rate = number of participants in non-MCI category / number of total participants.

  8. Remission rate-Hong Kong Montreal Cognitive Assessment (HK-MoCA)

    Time frame: 3-month follow-up

    Age- and education-corrected Hong Kong Montreal Cognitive Assessment (HK-MoCA). The HK-MoCA is a validated assessment for cognitive screening that takes into account different domains of cognition, which will enable the researchers to achieve a better understanding of the cognitive profile of the individual. MoCA will be used to classify participants into MCI and non-MCI category. The remission rate will be calculated as remission rate = number of participants in non-MCI category / number of total participants.

  9. VO2max

    Time frame: 3-month follow-up

    A VO2max test will be conducted using a calibrated motor-driven treadmill by continuous metabolic VO2 measurement using a COSMED Quark Series telemetric gas analysis system. The test will be performed using a modified bruce protocol. VO2, Borg's rating of perceived exertion (RPE) and heart rate (HR) will be continuously recorded. The maximal attainable heart rate will be recorded as the peak heart rate (HRpeak).

  10. Body fat mass

    Time frame: 3-month follow-up

    Body fat mass of participants will be measured by dual-energy X-ray absorptiometry (DXA).

  11. Lean mass

    Time frame: 3-month follow-up

    Lean mass of participants will be measured by dual-energy X-ray absorptiometry (DXA).

  12. Bone mineral density

    Time frame: 3-month follow-up

    Bone mineral density of participants will be measured by dual-energy X-ray absorptiometry (DXA).

  13. Habitual sleep

    Time frame: 3-month follow-up

    The Pittsburgh Sleep Quality Index (PSQI) is a standardized instrument to estimate sleep quantity and quality. The PSQI has been commonly used to distinguish people with primary insomnia from normal sleepers. The Chinese version of PSQI has been validated to have a satisfactory Cronbach's alpha of 0.82-0.83 and test-retest reliability of 0.85 among Hong Kong Chinese older adults. The overall score ranges from 0 to 24 while a higher score indicates worse sleep quality.

  14. Quality of Life-12-item Short Form Survey (SF-12)

    Time frame: 3-month follow-up

    The 12-item Short Form Survey (SF-12) will be used to assess the quality of life of the participant and higher scores (physical and mental sub-scale) indicate better quality of life.

  15. Depression level

    Time frame: 3-month follow-up

    Patient Health Questionnaire-9 (PHQ-9) will also be used to assess the mental health of the subjects. A PHQ-9 score of ≥ 10 has a sensitivity of 88% and a specificity of 88% for major depression. PHQ-9 scores of 5, 10, 15, and 20 correspond to mild, moderate, moderately severe, and severe depression, respectively. Results are similar in the primary care and obstetrics-gynecology samples. The PHQ-9 is a reliable and valid measure of depression severity and its brevity make the PHQ-9 a useful clinical and research tool.

  16. Mental health

    Time frame: 3-month follow-up

    Hospital Anxiety and Depression Scale (HADS) will used to measure the mental health of participants. It is a 7-item questionnaire having an overall score that ranges from 0 to 21 (with sub-scales for both anxiety and depression), with a higher score indicating more severe symptoms.

  17. Anxiety level

    Time frame: 3-month follow-up

    Generalized Anxiety Disorder 7-item (GAD-7) scale will be used to measure the anxiety level of participants. It is a 7-item questionnaire having an overall score that ranges from 0 to 21 with a higher score indicating more severe symptoms.

  18. Physical activity

    Time frame: 3-month follow-up

    The International Physical Activity Questionnaire (IPAQ) will be used to assess the activity level of the subjects.

  19. Balance performance

    Time frame: 3-month follow-up

    The balance ability of the subjects will be measured by single leg standing test. The longer standing duration indicates better balance performance.

Sponsors and collaborators

Lead sponsor

The University of Hong Kong

Other

Registry information

Official study title

Effectiveness of Different Exercise Intensities and Frequencies of Walking Exercise on Improving Cognitive Function in Older Adults With Mild Cognitive Impairment: a Pilot Randomized Controlled Trial

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Aug 17, 2020
Registry last updated
Nov 11, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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